高剂量丙种球蛋白在新生儿感染预防中的效果分析  

Effects of high dose immune globulin in prevention of neonatal infections

作　　者：朱馥荔 王巧玲[1] 黄砚屏 陈小蓓 苏静 ZHU Fu-li;WANG Qiao-ling;HUANG Yan-ping;CHEN Xiao-bei;SU Jing(Wuhan Children＇s Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430020,China)

机构地区：[1]华中科技大学同济医学院附属武汉儿童医院新生儿内科一病区,湖北武汉430020

出　　处：《中华医院感染学杂志》2018年第15期2377-2380,共4页Chinese Journal of Nosocomiology

基　　金：湖北省科技厅自然科学基金资助项目(EK2016D170058001317)

摘　　要：目的分析高剂量静脉注射丙种球蛋白(IVIG)在新生儿感染预防中的效果,为感染预防和控制工作提供客观依据。方法选取2016年3月-2017年5月医院收治的156例具有感染高危因素的新生儿作为研究对象,将其随机分为试验组和对照组,每组各78例。对照组患儿在常规疗法基础上给予常规剂量IVIG(400 mg/kg)静脉滴注,试验组患儿在常规疗法基础上给予高剂量IVIG(600mg/kg)静脉滴注。对两组患儿住院治疗期间的感染类型和感染发生率进行观察和比较;对两组患儿治疗前后的血清免疫球蛋白(Immunoglobulin,Ig)G、IgM、IgA水平进行检测和比较;观察和比较两组治疗期间的并发症发生情况。结果试验组感染患儿14例,感染率为17.95%,对照组感染患儿17例,感染率为21.79%,两组患儿感染率比较差异无统计学意义(χ2=0.362,P=0.547);两组患儿感染类型均以皮肤局部感染为主,两组患儿感染类型比较差异无统计学意义(χ2=0.051,P=0.997);治疗后,两组患儿的血清IgG、IgM水平均较治疗前升高(P<0.05),且试验组患儿的血清IgG水平高于对照组患儿(P<0.05);试验组和对照组患儿的治疗期间并发症发生率分别为23.08%和28.21%,两组患儿并发症发生率比较差异无统计学意义(χ2=0.538,P=0.463)。结论在高危新生儿感染的预防中应用高剂量IVIG,能够发挥一定提高患儿体液免疫功能的效果,但在降低感染率和并发症发生率方面的作用还有待于进一步的研究。OBJECTIVE To analyze the effects of high dose intravenous immune globulin（IVIG）in prevention of neonatal infections,so as to provide an objective basis for the prevention and control of infections.METHODS A total of 156 cases of newborns with high risk factors of neonatal infections from Mar.2016 to May 2017 were selected as the research subjects and randomly divided into the observation group and the control group,with 78 cases in each group.The newborns in the control group were treated with the conventional dose of IVIG（400 mg/kg）for intravenous injection on the basis of conventional therapy,while the newborns in the observation group were treated with the high dose IVIG（600 mg/kg）for intravenous infusion on the basis of conventional therapy.The types and the incidences of the infections during hospitalization in the newborns in the two groups were observed and compared.The serum IgG,IgM and IgA levels before and after the treatment of the newborns in the two groups were detected and compared.The incidences of the complications during the treatment of the newborns in the two groups were observed and compared.RESULTS In the observation group,14 cases were infected,the infection rate was 17.95%,and 17 cases in the control group were infected,the infection rate was 21.79%.There was no significant difference in the infection rate between the two groups（χ^2=0.362,P=0.547）.The infection types of the two groups were mainly localized skin infections,and there was no significant difference in the types of infection between the two groups（χ^2=0.051,P=0.997）.After the treatment,the serum IgG and IgM levels of the newborns in the two groups were significantly higher,（P〈0.05）,and the serum IgG level of the newborns in the observation group was significantly higher than that in control group（P〈0.05）.During the treatment,the incidences of the complications of the newborns in the two groups were 23.08%and 28.21%,and the difference of the incidence of the complications between the newborns in

关 键 词：高剂量 静脉注射丙种球蛋白 新生儿感染 预防 

分 类 号：R722.13[医药卫生—儿科]