婴幼儿肠道病毒组学研究进展  

Research advances in infant gut virome

作　　者：史以超[1] 彭丽华[1] 杨云生[1] SHI Yichao;PENG Lihua;YANG Yunsheng(Department of Gastroenterology and Hepatology,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院消化科,北京100853

出　　处：《解放军医学院学报》2018年第8期737-739,744,共4页Academic Journal of Chinese PLA Medical School

基　　金：北京市自然科学基金(S150010)~~

摘　　要：婴幼儿肠道病毒组是指肠道内的所有病毒、病毒颗粒及其遗传信息的总和。婴幼儿肠道病毒的形成始于婴儿出生,并在出生方式、母乳、饮食、环境等因素影响下逐渐扩张成熟。此外,肠道病毒组可以直接或间接调控宿主免疫、微生物代谢与营养、黏膜屏障形成,影响宿主的健康。然而,目前婴幼儿肠道病毒组研究相对滞后,需要进一步扩展完善病毒组数据库,深入研究肠道病毒组与其他微生物种群间的相关关系,并剖析其在婴幼儿发育中的作用。The infant virome refers to the sum of all viruses, virus-like particles, and their genetic information in the gut. The formation of gut virus in infants begins with the birth of the baby and gradually matures under the influence of factors such as birth pattern, feeding pattern, diet, and environment. In addition, the gut virome can directly or indirectly regulate host immunity, microbial metabolism and nutrition, and the formation of mucosal barriers affect the health of the host. However, the current research progress in infant＇s virome is relatively rare. It is necessary to further expand growth and the virome database, explore the correlation between the virome and other microbial populations, and analyze its role in the development of infants.

关 键 词：婴幼儿 肠道 病毒组 

分 类 号：R446.5[医药卫生—诊断学]