无创正压通气治疗OSA患者时对QTc离散度的影响  

Obstructive sleep apnea is associated with increased QT corrected interval dispersion: the effects of continuous positive airway pressure

作　　者：高英 卢翠莲[1] 严之红[1] 纪红[1] Gao ying;Lu cuilian;Yan zhihong;Ji hong(Geriatrics department,Aerospace Central Hospital,No.15,Yuquan Road,Haidian District,Beijing,100039,China)

机构地区：[1]航天中心医院,100039

出　　处：《临床心电学杂志》2018年第2期120-122,共3页Journal of Clinical Electrocardiology

摘　　要：目的探讨无创正压通气对重度阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)患者QTc间期离散度的影响。方法试验组入选65例重度OSA患者,AHI均>30,每位患者采集12导联心电图和睡眠呼吸监测;对照组为AHI<5的健康人,采集12导联心电图。计算两组QTc间期离散度,试验组进行无创正压通气3个月后,再次采集心电图,计算两组的QTc间期离散度。结果试验组QTc间期离散度(63.12±14.22ms)明显比对照组(29.21±6.29ms)延长,试验组经无创正压通气治疗后QTc间期离散度(40.02±15.23 ms)比治疗前QTc间期(63.12±14.22ms)缩短,二者有统计学差异(p=0.001)。结论持续无创正压通气治疗能够缩短重度OSA患者的QTc间期离散度。Objective The aim of the study was to determine the decrease of cardiovascular risk in patients with obstructive sleep apnea. Methods The study included 65 patients with severe obstructive sleep apnea who had an apnea-hypopnea index score of 30. Each patient underwent 12-channel electrocardiogram monitoring and polysomnography. Patients with an apnea-hypopnea index score of 5 were used as the control group. The control group also underwent electrocardiogram monitoring and polysomnography testing. The QT corrected interval dispersion levels of both groups were calculated.Three months after continuous positive airway pressure treatment,electrocardiogram recordings were obtained from the 65 patients with severe obstructive sleep apnea again, and their QT corrected interval dispersion values were calculated. Results The QTcd of the obstructive sleep apnea patients（63.12±14.22 ms） were significantly higher（p=0.001） than those of the control group（29.21±6.29 ms）. There were statistically significant differences between the QTcd before and after the continuous positive airway pressure treatment, with pretreatment QTcd of 63.12 ±14.22 ms and 3-monthpost-treatment values of 40.02 ±15.23 ms（p=0.001）. Conclusion The continuous positive positive airway pressure treatment can reduce QTcd interval dispersion levels.

关 键 词：OSA QTCD 无创正压通气 

分 类 号：R541.7[医药卫生—心血管疾病] R540.41[医药卫生—内科学]