外用苯烯莫德对特应性皮炎样小鼠的治疗作用  

Therapeutic effects of topical benvitimod in atopic dermatitis-like murine model

作　　者：兰宇贞 慕彰磊[1] 赵琰[1] 孙婧[1] 张建中[1] LAN Yuzhen;MU Zhanglei;ZHAO Yan;SUN Jing;ZHANG Jianzhong(Department of Dermatology,Peking University People＇s Hospita;Department of Dermatology,Peking University Third Hospita)

机构地区：[1]北京大学人民医院皮肤科,北京100044 [2]北京大学第三医院皮肤科,北京100191

出　　处：《中国麻风皮肤病杂志》2018年第8期468-472,共5页China Journal of Leprosy and Skin Diseases

摘　　要：目的:评价外用苯烯莫德对卡泊三醇(MC903)诱导的特应性皮炎样小鼠模型的治疗作用。方法:36只BALB/c小鼠,6只作为空白对照,30只给予MC903诱导特应性皮炎后再随机分为基质组、0.5%苯烯莫德组、1.0%苯烯莫德组、0.1%糠酸莫米松组和0.1%他克莫司组,治疗前后测量皮肤厚度、经皮水丢失(TEWL)、皮损内CD4^+T细胞、胸腺基质淋巴细胞生成素(TSLP)蛋白表达。结果:0.5%和1.0%苯烯莫德乳膏组皮损评分、耳部皮肤厚度、TEWL、皮损内CD4^+T细胞及TSLP蛋白水平较基质组均显著降低(P<0.05),1.0%苯烯莫德组疗效优于0.5%苯烯莫德组和他克莫司组(P<0.05),与糠酸莫米松组差异无显著性(P>0.05)。结论:外用苯烯莫德乳膏可减轻特应性皮炎样小鼠局部炎症反应。Objective： To assess the therapeutic effects of topical benvitimod in AD-like murine models induced by calcipotriol（ MC903）. Methods： Of 36 AD BALB/c murine models,6 were as normal controls and 30 were induced by MC903,and then,were divided into 5 groups： matrix group,0. 5% benvitimod group,1.0% benvitimod group,0.1% mometasone furoate group and 0.1% tacrolimus group（ 6 mice in each group）. The levels of lesion＇s thickness and TEWL,CD4~＋T cells and TSLP protein in the lesions were assessed before and after treatment. Results： After treatment,the levels of dermatitis score,lesion＇s thickness,TEWL,CD4~＋T cells and TSLP in 0.5% and 1.0% benvitimod group were lower than those in the matrix group（ Ps〈0.05）. 1.0% benvitimod was more effective than 0.5% benvitimod and tarcrolimus. The efficacy of 1.0% benvitimod was equivalent to 0.1% mometasone furoate（ P〉0.05）. Conclusion： Topical benvitimod can improve AD-like symptoms in BALB/c murine models.

关 键 词：特应性皮炎 苯烯莫德 小鼠模型 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]