德清地区2013-2016年淋球菌耐药监测结果分析  

Analysis of drug resistance monitoring results of Neisseria gonorrhoeae in Deqing area,2013-2016

作　　者：杨波 胡丽华[1] 赵建妹[1] YANG Bo;HU Li-hua;ZHAO Jian-mei(Clinical Laboratory,Institute for Prevention and Treatment of Dermatology in Zhejiang,Huzhou,Zhejiang 313200,China)

机构地区：[1]浙江省皮肤病防治研究所,浙江湖州313200

出　　处：《中国公共卫生管理》2018年第4期497-499,共3页Chinese Journal of Public Health Management

摘　　要：目的了解浙江德清地区淋球菌对抗菌药物敏感性及耐药谱的变化,为合理有效的治疗淋病提供依据。方法采用世界卫生组织推荐的琼脂稀释法测定抗菌药物最低抑菌浓度及高度耐四环素淋球菌(TRNG),采用纸片酸度定量法测定产β-内酰胺酶淋球菌菌株(PPNG)。结果 423株菌株对大观霉素和头孢曲松敏感率均为100%,未发现耐药株,但对头孢曲松中度敏感有24株(5.67%),对阿奇霉素敏感率为78.01%,而对青霉素耐药率占89.93%,耐药性最高的是环丙沙星,未发现敏感菌株。PPNG检测出213株(50.4%),4年间的变化差异无统计学意义(P>0.05);TRNG检测出197株(46.6%),变化趋势差异有统计学意义(χ~2=21.086,P<0.01)。结论大观霉素和头孢曲松仍是治疗淋病的有效药物,但头孢曲松中度敏感率有不同程度的增加,应当及时监测其敏感性变化。淋球菌对青霉素、四环素和环丙沙星的耐药率仍处于较高水平,对阿奇霉素耐药率也有不同程度增加。Objective To understand the susceptibility changes of antibacterial drug and drug resistance spectrum of Neisseria gonorrhoeae in Deqing area,and provide theoretical basis for the rational and effective treatment of gonorrhea. Methods The agar dilution method recommended by the World Health Organization（ WHO） was used to determine the minimum inhibitory concentration of antimicrobial agents and the highly resistant tetracycline gonococcal tetracycline gonorrhoeae（ TRNG）,and the paper-acid quantitative method was used to determine the strain PPNG producing lactamase-producing Neisseria gonorrhoeae. Results The sensitivity of 423 strains to spectinomycin and ceftriaxone was 100% without resistant strains,but there were 24 strains with moderate sensitivity to ceftriaxone（ 5. 67%）. The sensitivity rate to azithromycin was78. 01%. The resistance rate to penicillin reached 89. 93%. The highest drug resistance was ciprofloxacin and no sensitive strain was found. Two hundred and thirteen strains were detected by use of PPNG（ 50. 4%） and there were no statistical significance（ P〉0. 05） on the changes in the four years. One hundred and ninety-seven strains were detected by TRNG（ 46.6%）,and the trend of change with statistically significant in 4 years（ χ^2= 21. 086,P〈0. 01）. Conclusion Spectinomycin and ceftriaxone are still effective drugs in the treatment of gonorrhea,but the moderate sensitivity to ceftriaxone has increased to some extent,so the change of sensitivity should be monitored in time. The resistance of neisseria gonorrhoeae to penicillin,tetracycline and ciprofloxacin is still at a high level,and the resistance to azithromycin has increased to some extent.

关 键 词：淋球菌 淋病治疗 药敏实验 抗生素 敏感性 

分 类 号：R759.2[医药卫生—皮肤病学与性病学] R969.4[医药卫生—临床医学]