复方通络饮对脑梗死急性期患者神经功能及血管生长相关因子的影响  

Effects of Fufang Tongluo Decoction(复方通络饮) on Neurological Function and Vascular Growth Related Factors in Patients with Acute Cerebral Infarction

作　　者：惠振[1] 张臻年[1] 张敬华[1] 刘孔江[1] 肖婧[2] 李静波 郑培华[4] 王敬卿[1] HUI Zhen;ZHANG Zhennian;ZHANG Jinghua;LIU Kongjiang;XIAO Jing;LI Jingbo;ZHENG Peihua;WANG Jingqing(Nanjing Hospital of Chinese Medicine,Nanjing 210001;Jiangsu Provincial Second Chinese Medicine Hospital;Jiangsu Province Hospital of Integrated of Chinese and Western Medicine;Nanjing Integrated Traditional Chinese and Western Medicine Hospital)

机构地区：[1]南京市中医院,江苏省南京市金陵路1号210001 [2]江苏省第二中医院 [3]江苏省中西医结合医院 [4]南京市中西医结合医院

出　　处：《中医杂志》2018年第16期1383-1385,1390,共4页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81703975);十三五南京市卫生青年人才培养工程(QRX17185);南京市科技发展计划(201503031);南京市名中医工作室建设项目

摘　　要：目的观察复方通络饮治疗脑梗死急性期患者的临床疗效及可能机制。方法 158例脑梗死急性期患者随机分为治疗组86例和对照组72例。对照组采用西医基础治疗,治疗组在西医基础治疗同时加用复方通络饮,每日1剂,两组共治疗28天。治疗前和治疗14、28时进行美国国立卫生研究院卒中量表评分(NIHSS)、日常生活活动能力评分(BI指数),检测血清血管内皮生长因子(VEGF)、血管生成素1(Ang-1)、碱性成纤维细胞生长因子(b FGF)含量。结果与本组治疗前比较,两组患者治疗14、28天时NIHSS评分下降,BI指数升高,且在治疗14、28天时治疗组NIHSS评分低于对照组,BI指数高于对照组(P<0.05或P<0.01)。治疗组治疗14、28天时血清VEGF、Ang-1含量高于本组治疗前及对照组治疗后同时间点,血清b FGF含量低于本组治疗前及对照组治疗后同时间点(P<0.05或P<0.01)。结论复方通络饮可改善脑梗死急性期患者神经功能,提高日常生活活动能力,可能与调节血管生长相关因子表达有关。Objective To observe the therapeutic effects of Fufang Tongluo Decoction（复方通络饮） in treatment of acute cerebral infarction and its possible mechanism. Methods A total of 158 patients with acute cerebral infarction were randomly divided treatment group（86 cases） and control group（72 cases）. The control group was given western medicine basic treatment,and the treatment group was added Fufang Tongluo Decoction,1 dose per day.Both groups were treated for 28 days. Before and 14,28 days after treatment,NIH Stroke Scale（NIHSS） and Barthel index were performed. The serum vascular endothelial growth factor（VEGF）,angiogenin 1（Ang-1）,basic fibroblast growth factor（b FGF） were detected. Results Compared with before treatment,the NIHSS scores decreased and the BI index increased after 14 and 28 days of treatment. The NIHSS scores of the treatment group were lower than those of the control group after 14 and 28 days of treatment,and the BI index was higher than that of the control group（P〈0. 05 or P〈0. 01）. Serum VEGF and Ang-1 levels in the treatment group were higher than those in the treatment group before treatment and the control group after treament. The serum b FGF content was lower than that before treatment within group and the control group after treatment（P〈0. 05 or P〈0. 01）. Conclusion Fufang Tongluo Decoction can improve the neurological function and the activities of daily living in patients with acute cerebral infarction,which may be related to the regulation of the expression of vascular endothelial growth factors.

关 键 词：复方通络饮 脑梗死急性期 神经功能 血管新生 

分 类 号：R277.7[医药卫生—中医学]