高压氧联合养血清脑颗粒治疗突发性聋患者耳鸣及头晕的疗效分析  

Analysis of the therapeutic efficacy of hyperbaric oxygen combined with Yangxueqingnao granules for the treatment of tinnitus and dizziness in patients with sudden deafness

作　　者：彭小岭[1] 曾宪容[1] 潘福琼[1] 谢清明[2] 陈胡萍[1] 彭梅[1] Peng Xiaoling;Zeng Xianrong;Pan Fuqiong;Xie Qingming;Chen Huping;Peng Mei(Department of Hyperbaric Oxygen,People~ Hospital of Sichuan Province,Chengdu 610072,China)

机构地区：[1]四川省人民医院高压氧科,成都610072 [2]成都军区机关医院内二科

出　　处：《中华航海医学与高气压医学杂志》2018年第3期146-150,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨高压氧联合养血清脑颗粒对突发性聋患者耳鸣及头晕的临床疗效。方法2015年3月至2016年6月入住四川省人民医院高压氧科的符合纳入标准的124例突发性聋患者，使用随机数生成器产生随机号，并用不透光的信封隐藏试验分配方案的方法随机分为观察组（61例）和对照组（63例）。对照组只进行常规治疗，常规治疗包括改善循环、营养神经、激素及对症治疗；观察组在常规治疗基础上加用高压氧及养血清脑颗粒治疗（高压氧每日1次，每周5 d，10 d为1个疗程；养血清脑颗粒每次1袋，每日3次口服）。治疗2周后评价2组疗效，并于治疗后3个月和6个月通过电话随访患者耳鸣及头晕的疗效。结果2组患者均伴有耳鸣，观察组伴头晕42例，对照组伴头晕36例；治疗2周后及治疗后3个月、6个月随访，观察组耳鸣总有效率（83.61%、75.41%、77.05%）均高于对照组（65.08%、57.14%、58.73%），且2组比较差异均有统计学意义（P〈0.05）；治疗2周后及治疗后3个月、6个月随访，观察组头晕总有效率均为95.23%，均高于对照组（75.00%、80.56%、83.33%），且2组比较差异均有统计学意义（P〈0.05）。结论高压氧联合养血清脑颗粒治疗突发性聋伴耳鸣及头晕患者，疗效较好，值得临床推广。ObjectiveTo investigate the clinical effects of hyperbaric oxygen （HBO） combined with Yangxueqingnao granules on tinnitus and dizziness in patients with sudden deafness.MethodsOne hundred and twenty-four patients admitted into the Sichuan Provincial People＇s Hospital from March 2015 to June 2016 were randomly assigned to the observation group （n=61） and the control group （n=63） by using the random digital software to generate random number and opaque envelope hidden test scheme. The control group only received routine therapy, including improvement of circulation, nerve nutrition, hormone and symptomatic treatment, while the observation group was supplemented with HBO ＋ Yangxueqingnao granules in addition to routine therapy. The observation group received HBO therapy one session a day, 5 days a week and 10 days a treatment course. In addition, the patients in the observation group had Yangxueqingnao granules orally, one pack once and 3 times a day. After 2 weeks of treatment, therapeutic efficacy of the 2 groups was evaluated by the blinded method, and after 3 and 6 months of treatment, therapeutic effects on tinnitus and dizziness of the 2 groups were evaluated through medical follow-ups by telephone.ResultsAll the patients of the 2 groups had tinnitus, the observation group had 42 cases of dizziness, while the control group had 36 cases of dizziness. Following treatment for 2 weeks, 3 and 6 months, total effective rates of tinnitus in the observation group were respectively 83.61%, 75.41% and 77.05%, which were all higher than those of the control group （65.08%, 57.14%, 58.73%）, and statistical significance could be noted when comparisons were made between the 2 groups （P 〈 0.05）. Total effective rate of dizziness in the observation group after 2 weeks, 3 and 6 months of treatment was 95.23%, which was obviously better than those of the control group （75.00%, 80.56%, 83.33%）, and statistical significance could also be seen when comparisons were made between the 2 groups （P 〈 0.

关 键 词：高压氧 养血清脑颗粒 突发性聋 耳鸣 头晕 随机对照试验 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]