非瑟酮的药理作用研究进展  

Research progress in pharmacological action of fisetin

作　　者：叶冰洁 刘明鑫[1] 李威 唐艳红[1] YE Bingjie;LIU Mingxin;LI Wei;TANG Yanhong(Department of Cardiovascular Medicine,tlenmin Hospital of Wuhan University,Hubei Province,Wuhan 430061,China)

机构地区：[1]湖北省武汉市武汉大学人民医院心血管内科,湖北武汉430061

出　　处：《中国医药导报》2018年第23期22-25,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81370282)

摘　　要：非瑟酮(3,3′4′7-4羟基黄酮)是植物黄酮醇,是一种膳食类黄酮,存在于各种水果(草莓、苹果、芒果、柿子、猕猴桃和葡萄),蔬菜(西红柿、洋葱、黄瓜),坚果和葡萄酒中,在草莓、苹果、柿子中发现非瑟酮的含量最高。据估计,人体平均每日的非瑟酮摄入量是0.4 mg。非瑟酮具有强大的抗氧化、抗炎、抗肿瘤、降糖、神经保护以及心血管等多脏器保护作用。本文就非瑟酮的理化性质和药理作用等研究进展作一综述,为非瑟酮的进一步开发、现代研究和临床应用提供依据。Fisetin（3,3′4′7-4 hydroxyl flavone） is a plant flavonol, a dietary flavonoids, which exists in a variety of fruits（strawberry, apple, mango, persimmon, kiwi fruit and grape）, vegetables（tomato, Onion, cucumber）, nuts and wine.The highest levels of fisetin are found in strawberries, apples and persimmons. It is estimated that the average daily intake of fisetin is 0.4 mg. Fisetin has strong effect of antioxidant, anti-inflammatory, anti-tumor, hypoglycemic, neuroprotective and cardioascular protection. This paper reviews the physicochemical property and pharmacological effects of fisetin and provides a basis for further modern research and clinical application of fisetin.

关 键 词：非瑟酮 黄酮 药理作用 

分 类 号：R961.1[医药卫生—药理学]