孕中晚期乙肝患者抗病毒治疗服药依从性及影响因素  

Medication adherence and its influencing factors among the hepatitis B patients in the middle and later period of pregnancy

作　　者：杜晓娜[1] 田红卫[1] 吴惠萍[1] 董佳伟[1] 刘晓静[1] 董正洪[1] DU Xiaona;TIAN Hongwei;WU Huiping;DONG Jiawei;LIU Xiaojing;DONG Zhenghong(Department of Obstetrics and Gynecology,the Fifth Hospital of $hijiazhuang City,Hebei Province,$hijiazhuang 050021,China)

机构地区：[1]石家庄市第五医院妇产科,河北石家庄050021

出　　处：《中国医药导报》2018年第23期71-75,共5页China Medical Herald

基　　金：河北省石家庄市科学技术研究与发展计划项目(151460993)

摘　　要：目的调查孕中晚期乙肝患者抗病毒治疗服药依从性现状及其影响因素。方法选取2016年4月~2017年4月石家庄市第五医院收治的孕中晚期乙肝患者124例(单胎)为研究对象。采用Morisky量表对患者服药依从性进行评价;采用一般情况调查问卷、自制的乙肝相关知识问卷及服药信念问卷进行调查,采用Logistic回归分析患者服药依从性的影响因素。结果患者乙肝相关知识、服药信念和服药依从性整体水平较好;依从性好者占60.5%(75例)。多因素Logistic回归分析结果显示,文化程度(OR=0.578,95%CI:0.104~0.877)、父母有无乙肝(OR=0.392,95%CI:0.177~0.631)、乙肝确诊时间(OR=3.998,95%CI:1.188~5.285)、乙肝相关知识(OR=0.746,95%CI:0.389~0.847)、服药信念(OR=0.787,95%CI:0.259~0.977)均是服药依从性的影响因素(P<0.05)。结论医护人员要结合服药依从性的各项影响因素,有针对性地进行健康教育,以更好地提高患者的服药依从性,降低母婴传播率。Objective To investigate the status and influencing factors of medication adherence among hepatitis B patients in the middle and later period of pregnancy. Methods A total of 124 hepatitis B patients in the middle and later period of pregnancy treated in the Fifth Hospital of Shijiazhuang City from April 2016 to April 2017 were recruited.Medication adherence was assessed by the Morisky Medication Adherence Questionnaire（MAQ）. The main measuring instruments included the general Characteristics Questionnaire, the hepatitis B knowledge questionnaire and the Medication belief scale. Multiple Logistic regression analysis was used to analyze the influencing factors of medication adherence of hepatitis B patients. Results The score of overall hepatitis B related knowledge, the Medication belief and medication adherence were fair to middling, and the patients with good compliance accounted for 60.5%（75 cases）.Multivariate Logistic regression analysis showed that education level（OR = 0.578, 95%CI： 0.104-0.877）, parents have or no hepatitis B（OR = 0.392, 95%CI： 0.177-0.631）, diagnosis time of hepatitis B（OR = 3.998, 95%CI： 1.188-5.285）,hepatitis B related knowledge（OR = 0.746, 95%CI： 0.389-0.847）, medication beliefs（OR = 0.787, 95%CI： 0.259-0.977） were influencing factors for medication adherence（P〈0.05）. Conclusion Health care workers should combine the influencing factors of medication adherence to carry out targeted health education, so as to improve their medication adherence and reduce the vertical transmission rate of hepatitis B.

关 键 词：孕中晚期 乙肝 服药依从性 影响因素 

分 类 号：R512.62[医药卫生—内科学]