应变率成像评价蒽环类抗肿瘤药物对乳腺癌患者右心室功能的影响  

Effect of anthracycline on right ventricular function assessed by strain rate imaging in women with breast cancer

作　　者：刘俊峰[1] 刘伟亮[1] 陆海永 陈云璇[1] 温德惠[1] 王义成[1] 郜新春[1] LIU Junfeng;LIU Weiliang;LU Haiyong;CHEN Yunxuan;WEN Dehui;WANG Yicheng;GAO Xinchun(Department of Ultrasound,the First Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院超声科,河北张家口075000

出　　处：《中国医药导报》2018年第23期84-87,共4页China Medical Herald

基　　金：河北省医学科学研究重点课题计划(20160360)

摘　　要：目的探讨应变率显像技术对蒽环类化疗药物致乳腺癌患者右心室功能影响的评价作用。方法选取2015年10月~2016年10月在河北北方学院附属第一医院经病理确诊、采用CAF化疗方案的80例女性乳腺癌患者。所有研究对象采取自身对照的方式,分别于化疗前1 d及每次化疗周期的第5天获取常规超声心动图参数及应变率数据。结果在第6个化疗周期后,受试者的三尖瓣瓣环收缩期位移低于化疗前,右心室心肌功能指数高于化疗前(P<0.05)。应变/应变率显像发现,与治疗前相比,乳腺癌患者蒽环类药物化疗第6周期后整体径向应变、整体长轴应变率及整体圆周应变显著下降(P<0.05)。结论应变率成像能够早期反映蒽环类药物致乳腺癌患者右心室功能的改变。Objective To investigate the value of strain rate imaging for assessing the effect of anthracycline on right ventricular function in women with breast cancer. Methods From October 2015 to October 2016, 80 women pathologically diagnosed as breast cancer and undergoing CAF chemotherapy protocol at the First Affiliated Hospital of Hebei North University were recruited in this study. By the way of self-control, conventional echocardiography and strain rate imaging were performed to assess the right ventricular function at the first day before starting chemotherapy and the fifth day of every 5 chemotherapy cycles. Results The tricuspid annular plane systolic excursion was significantly lower, while the right ventricular myocardial performance index was significantly higher in women after the sixth cycles of chemotherapy compared with those before chemotherapy（P〈0.05）. Strain rate imaging showed that global longitudinal strain rate, global radial strain and global circumferential strain in women after the sixth cycle of chemotherapy were significantly lower than those before chemotherapy（P〈0.05）. Conclusion Strain rate imaging can reflect the change of right ventricular function at an early stage in breast cancer women treated with anthracycline.

关 键 词：应变率成像 蒽环类药物 乳腺癌 右心室功能 

分 类 号：R445.1[医药卫生—影像医学与核医学]