重症肺炎患者肺泡灌洗液NGAL的临床意义  

Measurement and clinical significance of neutrophil gelatinase associated lipocalin concentration in patients with severe pneumonia

作　　者：唐玮欣 陈丽芳[1] 陈兰春[1] 李展汉 丘自挺[1] 余雪涛[1] TANG Wei-xin;CHEN Li-fang;CHEN Lan-chun(The People＇s Hospital Of Longgang District,Shenzhen City,Shenzhen 518172,China)

机构地区：[1]深圳市龙岗区人民医院,广东深圳518172

出　　处：《吉林医学》2018年第9期1609-1611,共3页Jilin Medical Journal

基　　金：深圳市龙岗区科技计划资助项目[项目编号:YLWS20150514114457328]

摘　　要：目的:探讨重症肺炎患者肺泡灌洗液中NGAL的检测与病情严重程度及预后的关系。方法:临床选取50例患者,其中29例重症肺炎患者设为A组,21例非重症肺炎患者设为B组。检测两组患者肺泡灌洗液NGAL、血清NGAL、血浆超敏C-反应蛋白、血清PCT的浓度,同时进行急性生理与慢性健康评分(APACHE-Ⅱ),记录预后。结果:A组患者肺泡灌洗液NGAL、血清NGAL、血浆超敏C-反应蛋白、血清PCT显著高于B组,A组患者死亡率较B组明显升高,差异均有统计学意义(P<0.05),肺泡灌洗液NGAL、血清NGAL与APACHE-Ⅱ评分均呈正相关(r=0.556,P<0.001;r=0.348,P=0.013)。结论:重症肺炎患者肺泡灌洗液NGAL的浓度明显高于非重症肺炎患者,检测肺泡灌洗液中NGAL可作为判断患者病情及预后的指标之一。Objective To measure the concentration of neutrophil gelatinase associated lipocalin in the bronchoalveolar lavage fluid（ b NGAL） and investigate it＇s clinical significance. Method 50 patients with pneumonia were enrolled,of which 29 cases with severe pneumonia criteria as group A,and 21 cases without severe pneumonia as group B. The b NGAL,serum NGAL（ s NGAL）,plasma high sensitivity C reactive protein and serum PCT were detected in two groups of patients. The acute physiology and chronic health score（ APACHE-Ⅱ） was recorded,and the prognosis was recorded. Results The b NGAL,s NGAL,plasma high sensitivity C reactive protein and serum PCT of the group A was significantly higher,the difference was statistically significant（ P 0. 05）. The b NGAL and s NGAL were positively correlated with APACHE-Ⅱ score（ r = 0. 556,P 0. 001; r = 0. 348,P =0. 013）. Conclusion The concentration of b NGAL of patients with severe pneumonia is significantly higher than those without severe pneumonia patients. Measuring the concentration of b NGAL can be used as an indicator of patients＇ condition and prognosis.

关 键 词：重症肺炎 NGAL APACHE-Ⅱ评分 

分 类 号：R563.1[医药卫生—呼吸系统]