金佛山雪胆块根的化学成分研究  

Chemical Constituents from the Tubers of Hemsleya pengxianensis var. jinfushanensis

作　　者：王文雪[1,2] 娄京荣 牟艳玲[2] 郑重飞[2] 李莹[2] 姚庆强[2] WANG Wen-xue;LOU Jing-rong;MU Yan-ling;ZHENG Zhong-fei;LI Ying;YAO Qing-qiang(Sehool of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,China;Institute of Materia Medica,Shandong Academy of Medical Sciences,Key Laboratory for Biotech-Drugs Ministry of Health,Key Laboratory for Rare ＆ Uncommon Diseases of Shandong Province,Jinan 250062,China)

机构地区：[1]济南大学-山东省医学科学院/医学与生命科学学院,山东济南250200 [2]山东省医学科学院药物研究所/国家卫生部生物技术药物重点实验室/山东省罕少见病重点实验室,山东济南250062

出　　处：《中药材》2017年第12期2844-2848,共5页Journal of Chinese Medicinal Materials

基　　金：山东省自主创新及成果转化专项(2014ZZCX02105)

摘　　要：目的:研究金佛山雪胆块根乙酸乙酯部位的化学成分。方法:利用硅胶柱色谱、ODS反相柱色谱、HPLC制备色谱等技术分离纯化化合物,根据化合物的波谱数据分析鉴定化合物结构。结果:从金佛山雪胆块根乙酸乙酯部位中共分离鉴定了11个化合物,分别为:scandenoside R8(1)、3-O-β-D-glucopyranosyl-3β,27-dihydroxycucurbita-5,24(Z)-diene-11-one-27-O-β-D-glucopyranoside(2)、短柄雪胆苷A(3)、scandenoside R3(4)、scandenoside R4(5)、jinfushanoside J(6)、carnosiflosideⅤ(7)、carnosiflosideⅢ(8)、scandenoside R6(9)、jinfushanoside K(10)、雪胆双糖(11)。结论:其中,化合物4、5、7、9、11为首次从该植物中分离得到,并首次归属了化合物11的羟基信号。Objective： To study the chemical constituents of the ethyl acetate extract of the tubers of Hemsleya pengxianensis var. jinfushanensis. Methods： The compounds were isolated by various chromatographic techniques,including silica gel,ODS reversed phase column and preparative high-performance liquid. The structures were identified on the basis of MS and NMR data. Results： Eleven compounds were obtained from the ethyl acetate fraction of the tubers of Hemsleya pengxianensis var. jinfushanensis and identified as scandenoside R8（ 1）,3-O-β-D-glucopyranosyl-3β,27-dihydroxycucurbita-5,24（ Z）-diene-11-one-27-O-β-D-glucopyranoside（ 2）,delavanoside A（ 3）,scandenoside R3（ 4）,scandenoside R4（ 5）,jinfushanoside J（ 6）,carnosifloside Ⅴ（ 7）,carnosifloside Ⅲ（ 8）,scandenoside R6（ 9）,jinfushanoside K（ 10）,amabiose（ 11）. Conclusion： Compounds 4,5,7,9,11 are isolated from this plant for the first time,and the hydroxyl signals of compound 11 are identified for the first time.

关 键 词：金佛山雪胆 葫芦烷型三萜 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]