青阳参总苷对社会挫败应激模型大鼠的抗抑郁作用研究  

Effects of Qingyangshen Glycosides on Depression in Social Defeat Stress Model of Rats

作　　者：张萌 高博 李勇辉[2] 杨庆雄[1,3] ZHANG Meng;GAO Bo;LI Yonghui;YANG Qingxiong(School of Chemistry and Materials Science,Guizhou Normal University-,Guiyang 550000 China;School of Karst,Guizhou Normal University,State Engineering Technology Institute for Karst Desertifieation Control,Guiyang 550000 China;Chinese Academy of Sciences,Key Laboratory-of Mental Health,Institute of Psychology,Beijing 100101 China)

机构地区：[1]贵州师范大学化学与材料科学学院,贵州贵阳550000 [2]中国科学院心理研究所中国科学院心理健康重点实验室,北京100101 [3]贵州师范大学喀斯特研究院国家喀斯特石漠化防治技术研究中心,贵州贵阳550000

出　　处：《中国民族民间医药》2018年第15期17-20,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然科学基金项目(31760091)

摘　　要：目的:评价青阳参总苷(QYS)的抗抑郁活性。方法:60只大鼠分为对照组、模型组、QYS低中高剂量组,氟西汀作为阳性对照组。首先进行10 d社会挫败应激,第5天开始灌胃给药,然后测试糖水偏爱、旷场、惊跳反射和前脉冲抑制等行为。结果:与模型组相比,QYS和氟西汀能显著抑制应激8 d的糖水偏爱下降,旷场试验大鼠自主活动性和不动时间没有显著变化,而QYS高剂量组和阳性对照组能增加大鼠僵直时间;大鼠惊跳反射和前脉冲抑制没有显著变化,而QYS高剂量组能显著降低大鼠105d B惊跳反射幅值;与模型组间的差异有统计学意义(P<0.05)。结论:QYS对社会挫败应激大鼠抑郁行为具有调节作用。Objective To evaluate the antidepressant activity of Qingyangshen glycosides（ QYS）. Methods 60 rats were divided into control group,model group and QYS treatment group,and fluoxetine wasused as positive control group. Firstly,rats were stressed 10 days by a social defeat stress program,and drugs were administered intragastrically on the 5 th day of the stress. Thebehavioral effectswere tested using syruppreference,open field,startle reflexand prepulse inhibitiontests. Results QYS and fluoxetine could significantly inhibit the decrease of syrup preference value induced by stress,and no significant change was observed in the autonomic activity and immobility of rats. However,the freezing time was increased in high dose of QYS and positive control groups in the open field tests. Nodifference was observed between startle reflex and prepulseinhibition in rats after stress,but the startle reflex amplitude of rats on 105 d B was significantly inhibited in the high dose of QYS group,being comparing with the stress group. And the difference was statistically significant between the model group（ P〈0. 05）. Conclusion QYS showed an antidepressanteffect onsocial defeat stress rats.

关 键 词：青阳参总苷 社会挫败应激 抗抑郁 

分 类 号：R285.5[医药卫生—中药学]