特应性皮炎患者的平均血小板体积及其与瘙痒程度的关系  

Mean platelet volume and its relation with degree of pruritus in patients with atopic dermatitis

作　　者：罗浩 陈娜[1] 钟江[1] 张衍[1] 冯杲[1] 吴志洪[1] LUO Hao;CHEN Na;ZHONG Jiang;ZHANG Yan;FENG Gao;WU Zhi-hong(Department of Dermatology,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学第一附属医院皮肤科,南宁市530023

出　　处：《广西医学》2018年第15期1645-1646,共2页Guangxi Medical Journal

基　　金：国家自然科学基金(81660728)

摘　　要：目的探讨特应性皮炎(AD)患者的平均血小板体积(MPV)及其与瘙痒程度的相关性。方法纳入110例AD患者(AD组)及50例健康体检者(正常对照组)。根据疼痛视觉模拟量表(VAS)评分将AD患者分为轻度瘙痒组39例、中度瘙痒组37例及重度瘙痒组34例。比较AD组与正常对照组、不同瘙痒程度组间的MPV,并分析AD患者的MPV与VAS评分的相关性。结果 AD组的血清MPV低于正常对照组(P<0.05)。轻度瘙痒组、中度瘙痒组和重度瘙痒组MPV依次降低(P<0.05),且AD患者MPV与VAS评分呈负相关(P<0.05)。结论 AD患者的MPV下降,MPV可作为AD的炎症指标,其可能与AD的发生及瘙痒程度有关。Objective To investigate the mean platelet volume（MPV） and its relation with the degree of pruritus in patients with atopic dermatitis（AD）. Methods A total of 110 AD patients（AD group） and 50 healthy individuals receiving medical examination（normal control group） were enrolled. The AD patients were divided into mild pruritus group（n = 39）,moderate pruritus group（n = 37）and severe pruritus group（n = 34） using the Visual Analogue Scale（VAS） score. The MPV was compared between the AD group and the normal control group,and was also compared among the groups with different degrees of pruritus. The correlation of MVP with VAS score was analyzed in AD patients. Results Serum MPV of the AD group was lower than that of the normal control group（P〈0. 05）. MPV decreased in the order of the mild pruritus group,moderate pruritus group and severe pruritus group（P〈0. 05）. MVP negatively correlated with VAS score in AD patients（P〈0. 05）. Conclusion MPV decreases in the AD patients. MPV,as an inflammatory indicator for AD,may be associated with the occurrence of AD and the degree of pruritus.

关 键 词：特应性皮炎 平均血小板体积 瘙痒 视觉模拟评分法 

分 类 号：R751[医药卫生—皮肤病学与性病学]