维甲酸诱导基因Ⅰ和慢性丙型肝炎的研究进展  

Progress in studies on retinoic acid inducible gene Ⅰ and chronic hepatitis C

作　　者：王方平[1] 张平安[1] 杨晓燕 Wang Fangping;Zhang Ping＇an;Yang Xiaoyan(Department of Laboratory Science,the People′s Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院检验科,430060

出　　处：《中华实验和临床病毒学杂志》2018年第4期445-448,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：丙型肝炎病毒（Hepatitis C virus，HCV）急性感染期一般是无症状的，大多数感染者不能清除该病毒容易发展成慢性感染，少部分感染者甚至发展为肝硬化、肝癌。传统的治疗方法是聚乙二醇干扰素联合利巴韦林方案，但抗病毒疗效不佳且不良反应较大，这可能与HCV能够通过多种机制逃避宿主的免疫反应有关。固有免疫应答是机体抵抗病原微生物的第一道防线，维甲酸诱导基因Ⅰ（Retinoic acid inducible geneⅠ，RIG-Ⅰ）作为模式识别受体，在识别HCV病毒，启动免疫应答中发挥重要作用。Acute infection with hepatitis C virus is generally asymptomatic. Most patients can not clear the virus and are easy to develop into chronic infection, while a small number of patients even develop into cirrhosis, or liver cancer. The traditional treatment is combined pegylated interferon with ribavirin, but the antiviral effect is poor and the adverse reactions are large, which may be related to the ability of HCV to escape the host′s immune response through various mechanisms. The innate immune response is the first line of defense against pathogenic microorganisms. Retinoic acid inducible geneⅠ（RIG-Ⅰ） plays an important role in identifying HCV virus and initiating immune response as a pattern recognition receptor.

关 键 词：肝炎病毒 丙型 慢性 维甲酸诱导基因Ⅰ 

分 类 号：R512.63[医药卫生—内科学]