藏药抗肿瘤药材及复方整理研究  

Arrangement on antitumor medicinal materials and compound prescriptions of Tibetan medicine

作　　者：黄旭峰[1] 泽翁拥忠[2] 古锐[2] 钟世红[3] 降拥四郎 刚焕晨雷 HUANG Xu-feng;ZEWENG Yong-zhong;GU Rui;ZHONG Shi-hong;JIANGYONG Si-lang;GANGHUAN Chen-lei(College of Pharmacy,Chengdu Universicity of Traditional Chinese Medicine,Chengdu 611137,China;College of Ethnomedicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Chengdu Medical College,Chengdu 610083,China)

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]成都中医药大学民族医药学院,四川成都611137 [3]成都医学院,四川成都610083

出　　处：《中草药》2018年第15期3721-3728,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目:基于分子古生物学的藏药渣驯形成机制研究(83571699);四川省科技厅科普培训项目(2017KZ0063)

摘　　要：藏药是国内传统医药的重要组成部分,但其中有很多具有抗肿瘤功效的药物无人问津。通过文献整理与访谈,整理出具有抗肿瘤功效的60种药材和6种复方。从植物名、拉丁学名、藏文名、藏药传统功效、抗癌有效成分和机制等方面对药材进行总结归纳。60种药材分属36个科,且大多为高原品种;这些品种中直接抑制肿瘤细胞生长与增殖的药材有27种;诱导肿瘤细胞凋亡的药材有12种;诱导肿瘤细胞分化的药材有2种;增强机体免疫功能的药材有3种。藏药抗肿瘤药物开发潜力大,对抗肿瘤新药的开发提供了可能性。Tibetan medicine is an important part of traditional medicine in China, while many of them with antitumor activity still be neglected. Through literature collation and interviews, we sort out 60 kinds of medical materials and six kinds of compound with antitumor and pharmacological activity. The medicinal materials were described by the aspects of Latin name, botanical name, Tibetan name, the traditional efficacy of Tibetan medicine, and anticancer active ingredients and mechanisms. The results found that 60 kinds of medical materials belong to 36 families, and mostly plateau varieties. There are 27 kinds of medicinal herbs directly inhibiting the growth and proliferation of tumor cells in these varieties; 12 kinds of medicinal herbs inducing tumor cell apoptosis; two kinds of medicinal herbs inducing tumor cell differentiation; three kinds of medicinal herbs enhancing organism immunity. In summary, Tibetan medicine has great potential for development of anticancer drugs and offers the possibility of developing new drugs against tumors.

关 键 词：藏药 抗肿瘤 细胞生长 细胞凋亡 细胞分化 

分 类 号：R285[医药卫生—中药学]