阿西美辛微囊的制备与质量评价  

Preparation and Quality evalution of Acemetacin microcapsules

作　　者：万蒞 张友智[2] Wan Li;Zhang Youzhi(Hubei Provincial Maternal and Child Healthcare Hospital,Wuhan 430070,China;Affiliated Tianyou Hospital of Wuhan University of Science and Technology,Wuhan 430064,China)

机构地区：[1]湖北省妇幼保健院,武汉430070 [2]武汉科技大学附属天佑医院,武汉430064

出　　处：《北方药学》2018年第9期136-138,共3页Journal of North Pharmacy

摘　　要：目的:研究阿西美辛微囊的制备工艺,并对其进行质量评价。方法:以海藻酸钠和壳聚糖为囊材,采用机械乳化法制备阿西美辛微囊,并对微囊的外观形态、粒径、包封率、载药量和体外释放度进行研究。结果:海藻酸钠和壳聚糖的用量均为3%,所制得微囊外观形态圆整,大小均匀,粒径为60~70μm的微囊占76.40%,包封率为73.57%,载药量23.54%,24h累积释放度93.61%。结论:所制备的阿西美辛微囊工艺简单、可靠,具有缓释效果。Objective：To study the preparation technologyof acemetacin microcapsules, and their quality evalution. Methods：Sodium alginate and chitosan were used as capsule materials and the acemetacin microcapsules were prepared by a mechanical emulsification method, Its appearance ,particle size ,encapsulation efficiency, drug loading and release degree in vitro were studied. Results ：The dosage of sodium alginate and chitosan were 3% respectively,the prepared microeapsules spherical with smooth surface, the size of uniform, and the particle size distribution was 76.40% in 60~70μm,the average encapsulation efficacy was 73.57%,the average drug loading was 23.54%,and the accumulated release amount is 93.61% in 24h.Conelusion： To prepare acemetacin microcapsules is simple and reliable, microcapsules could provide some controlled-release effect.

关 键 词：阿西美辛 微囊 制备工艺 体外释放 

分 类 号：R943[医药卫生—药剂学]