多聚物纳米抗生素的研究进展  

Progress of polymer nano-antibiotic formulations

作　　者：杜子秀[1] 陈娟 Du Zi-xiu;Chen Juan(School of Pharmacy,Shanghai Jiao Tong University,Shanghai 20024)

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《中国抗生素杂志》2018年第8期990-995,共6页Chinese Journal of Antibiotics

摘　　要：多聚物纳米抗生素制剂目前尚处于起步阶段,但已有多种聚合物可以作为抗生素的载体,如聚氰基丙烯酸烷基酯、聚(乳酸-羟基乙酸)(PLGA)、壳聚糖、聚酰胺-胺型树枝状高分子(PAMAM)、两亲性嵌段共聚物等。本文主要回顾了上述聚合物的抗生素纳米制剂的发展状况,并分析展望其未来的应用前景。Polymer nano-antibiotic formulations are still in their infancy, but there are currently many polymers that can be used as carriers for antibiotics, such as polyalkylcyanoacrylates, poly （lactic-co-glycolic acid） （PLGA）, chitosan, polyamine-amine dendrimers （PAMAM）, and amphiphilic block copolymers. This article reviews the development of antibiotic nano-formulations of the aforementioned polymers and analyzes the prospects for future social and economic benefits.

关 键 词：多聚物纳米抗生素 抗生素的载体 聚合物 纳米颗粒 

分 类 号：R978.1[医药卫生—药品]