参芪妇康颗粒成型工艺研究  

Forming process of Shenqi Fukang Granules

作　　者：孙臻 陈明聪[2] 汪杰[2] 张影[2] 黄祖光[2] 高华宏 SUN Zhen;CHEN Ming-cong;WANG Jie;ZHANG Ying;HUANG Zu-guang;GAO Hua-hong(Sanya City Womenfolk ＆ Infant Health Care Hospital,Sanya 572000,China 2.Sanya Traditional Chinese Medicine Hospital,Sanya 572000,China 3.Guangdong Institute of Traditional Chinese Medicine,Guangzhou 510000,China)

机构地区：[1]三亚市妇幼保健院,海南三亚572000 [2]三亚市中医院,海南三亚572000 [3]广东省中药研究所,广东广州510000

出　　处：《中草药》2018年第16期3849-3853,共5页Chinese Traditional and Herbal Drugs

基　　金：三亚市医疗卫生科技创新项目:参芪妇康颗粒的研制(2016YW03)

摘　　要：目的研究参芪妇康颗粒干法制粒最佳成型工艺条件。方法以颗粒的一次性成型率和吸湿率作为评价指标,采用L9(34)正交试验法优选最佳辅料配比。结果以干浸膏-微粉硅胶-可溶性淀粉-麦芽糊精77.5∶2.5∶5∶15为最佳辅料配比;干法制粒工艺条件参数为车间温度20℃,50%相对湿度,挤压压力12 kg/cm3,侧封压力14 kg/cm3,挤压频率22 Hz,制粒频率52 Hz,送料频率19 Hz。结论优选的参芪妇康颗粒干法制粒成型工艺稳定可行,成品流动性、溶化性良好,吸湿性小,为大生产提供了可靠实验依据。Objective To study the optimum molding process condition of dry granulating of Shenqi Fukang Granules（SFG）. Methods Using primary formation rate and hygroscopicity rate as evaluation indicators; The optimal excipient ratio was optimized by L9（34） orthogonal test method. Results The ratio of dry extract-micro silica gel-soluble starch-maltodextrin 77.5∶2.5∶5∶15 was the optimal ratio of excipients; Dry granulating conditions parameters： workshop temperature of 20 oC, relative humidity of 50%, extrusion pressure of 12 kg/cm3, side seal pressure of 14 kg/cm3, extrusion frequency of 22 Hz, granulation frequency of 52 Hz, and feeding frequency of 19 Hz. Conclusion The optimized SFG dry granulating molding process is stable and feasible. The finished product showed a fine liquidity, good dissolubility and little hygroscopicity, which provides a reliable experimental basis for large-scale production.

关 键 词：参芪妇康颗粒 干法制粒 正交设计 成型工艺 一次性成型率 吸湿率 

分 类 号：R283.6[医药卫生—中药学]