一起接种无细胞百日咳-白喉-破伤风联合疫苗和脊髓灰质炎减毒活疫苗偶合间质性肺炎死亡病例的调查处理  

Investigation and disposal of a death case of interstitial pneumonia coupling with the inoculation of DTaP and OPV

作　　者：许波[1] 文海蓉[1] 彭时辉[1] 张艳霞[1] 廖征[1] 周义生[1] XU Bo;WEN Hairong;PENG Shihui;ZHANG Yanxia;LIAO Zheng;ZHOU Yisheng(Nanchang Center for Disease Control and Prevention,Jiangxi 330038,China)

机构地区：[1]南昌市疾病预防控制中心,江西330038

出　　处：《医学动物防制》2018年第9期897-899,共3页Journal of Medical Pest Control

基　　金：江西省卫生计生委科技计划项目(20186022)

摘　　要：目的总结接种疫苗后出现疑似预防接种异常反应(Adverse Event Following Immunization,AEFI)尤其是死亡病例的处置经验,为科学有效地应对预防接种突发事件提供参考。方法对一起婴儿接种无细胞百白破疫苗和脊髓灰质炎减毒活疫苗后偶合死亡的事件进行调查、诊断和处置。结果预防接种异常反应调查诊断小组诊断为:由于间质性肺炎引起缺氧导致急性呼吸衰竭而死亡,不属于预防接种异常反应,属于偶合症。结论应强调规范接种,尽量减少预防接种不良反应事件的发生。出现预防接种异常反应后及时处置,但不能单纯考虑预防接种不良反应的发生,也应考虑偶合其他疾病,从而减少由于偶合其他疾病给预防接种带来的负面影响。Objective To summarize the suspected Adverse Event Following Immunization（AEFI） after vaccination,especially the experience in the disposal of deaths cases,and provide reference for scientifically and effectively dealing with vaccination emergencies. Methods One case of accidental death was investigated,diagnosed and disposed where an infant died accidentally after the inoculation of DTaP and OPV. Results The diagnosis group of AEFI diagnosed that the infant was died of acute respiratory failure due to hypoxia caused by interstitial pneumonia, which was excluded from AEFL but an incidental disease. Conclusion Inoculation should be standardized to reduce adverse reaction following immunization. It should be deal with in time when AEFI appears. Not only the occurrence of adverse reaction following immunization but also the coupling of other diseases should be considered to reduce negative impact on inoculation brought by the coupling of other diseases.

关 键 词：预防接种 无细胞百日咳-白喉-破伤风联合疫苗 脊髓灰质炎减毒活疫苗 偶合症 间质性肺炎 死亡 

分 类 号：R186[医药卫生—流行病学]