针刺戒烟的随机对照研究  

A randomized controlled trial on smoking cessation by acupuncture

作　　者：王莹莹[1] 刘朝[2,3] 吴远 佟帅[4] 苏李[4] 袁桂洪[5] 荆菊梅 张路 杨金生[1,7] Wang Yingying;Liu Chao;Wu Yuan;Tong Shuai;Su Li;Yuan Guihong;Jing Jumei;Zhang Lu;Yang Jinsheng(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;Center for Tobacco Epidemiology and Smoking Cessation,China-Japan Friendship Hospital,Beijing 100029,China;Cooperation Center for Smoking Cessation and Respiratory Disease Prevention of WHO,Beijing 100029;Haidian Hospital of Beijing City,Beijing 100080,China;Chinese Medical Hospital of Jintan City,Changzhou 213200,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Shaanxi University of Chinese Medicine,Shaanxi 712046,China)

机构地区：[1]中国中医科学院针灸研究所,北京100700 [2]中日友好医院烟草病学及戒烟中心 [3]世界卫生组织戒烟与呼吸疾病预防合作中心 [4]北京市海淀医院 [5]江苏省常州市金坛区中医院 [6]中国中医科学院西苑医院 [7]陕西中医药大学

出　　处：《北京中医药大学学报》2018年第7期605-610,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家中医药行业科研专项基金项目(No.201307014);北京中医药科技发展资金项目(No.JJ2018-97)~~

摘　　要：目的评价针刺戒烟及对戒断症状的疗效。方法采用随机对照的研究方法,将招募的自愿戒烟者按照1∶1的中央随机方法,分为针刺组和尼古丁贴片组。针刺组受试者接受针刺戒烟干预,穴位选择百会、列缺、合谷、足三里、三阴交和太冲,各穴均采用平补平泻法;同时使用电子针疗仪在列缺、足三里上进行连续波(15 Hz)刺激30 min,每周治疗3次。尼古丁贴片组受试者接受贴片戒烟干预。2组分别给予8周的针刺治疗和尼古丁替代疗法,随访16周。比较2组基于呼气CO含量的24 h点戒断率差异,以及尼古丁依赖程度评估量表(FTND)、吸烟强度指数量表(HSI)、明尼苏达尼古丁戒断症状量表(MNWS)、吸烟渴求简短问卷(QSU)评分的变化,采用意向性统计分析法。结果共纳入200例受试者,随访结束时,针刺组脱落30例,尼古丁贴片组脱落27例,均无不良事件发生。治疗8周后,针刺组的基于呼气CO的24 h点戒断率为42.00%,与尼古丁贴片组的46.00%相比差异无统计学意义(P>0.05);24周随访时,针刺组的戒烟率为43.00%,与尼古丁贴片组的44.00%相比差异无统计学意义(P>0.05)。治疗8周后,针刺组的FTND、HSI、MNWS、QSU与尼古丁贴片组的结果相比,差异无统计学意义(P>0.05);24周随访时,针刺组的FTND、HSI、MNWS、QSU与尼古丁贴片组的结果相比,差异无统计学意义(P>0.05)。结论针灸是一种安全有效的戒烟干预措施,并能够有效缓解戒断症状。Objective To review smoking cessation by acupuncture and its curative effect on abstinence symptoms. Methods The volunteers trying to quit smoking were divided, according to central randomization （ 1 ： 1 ） , into acupuncture group and nicotine patch group （ patch group） , and a randomized controlled trial was applied. The acupuncture group was given quit-smoking intervention by needling in Baihui （ GV20）, Lieque （ LU7 ）, Hegu （ LI4 ）, Zushanli （ ST36 ）, Sanyinjiao （ SP6 ） and Taichong （LR3） , and acupuncture manipulation was of neutral supplementation and draining. Meanwhile electro- acupuncture apparatus was used to stimulate Lieque （LU7） and Zushanli （ST36） with continuous wave （15 Hz） for 30 min for 3 times a week. The patch group was given quit-smoking intervention with nicotine patches. All groups were intervened for 8 weeks and followed up for 16 weeks. The difference in abstinence rate based on expiratory CO content at 24-h time point was compared between 2 groups. The score changes of Fagerstrom Test for Nicotine Dependence （FTND）, heaviness of smoking index （HSI）, Minnesota Nicotine Withdrawal Scale （MNWS） and Brief Questionnaire of Smoking Urges （QSU-Brief） were compared by using intentional statistical analysis. Results There were totally 200 cases chosen, and at the end of follow-up, there were 30 missed in acupuncture group and 27 in patch group. There were no adverse events observed in 2 groups. After intervention for 8 weeks, the abstinence rate based on expiratory CO content at 24-h time point was 36.00% in acupuncture group and 46.00% in patch group （P 〉0.05）. During 24-week follow-up period, the abstinence rate was 43.00% in acupuncture group and 44.00% in patch group （P 〉 0.05）. After intervention for 8 weeks, the difference in FTND, HIS, MNWS and QSU-Brief had no statistical significance between 2 groups （P 〉 0.05）. During 24-week follow-up period, the difference in FTND, HIS, MNWS and QSU-Brief had no statistical

关 键 词：针刺 戒烟 疗效 戒断率 

分 类 号：R246.9[医药卫生—针灸推拿学]