玉屏风颗粒对牛奶蛋白过敏患儿Th17/Treg平衡的影响  

Effect of Yupingfeng granule on Th17/Treg balance in children with milk protein allergy

作　　者：张圆圆 汤建萍[1] 罗勇奇[1] 韦祝[1] Zhang Yuanyuan;Tang Jianping;Luo Yongqi;Wei Zhu(Department of Dermatology,Hunan Children ＇s Hosptial,Changsha 410007,China)

机构地区：[1]湖南省儿童医院皮肤科,长沙410007

出　　处：《中国医师杂志》2018年第8期1171-1175,共5页Journal of Chinese Physician

基　　金：湖南省中医药科研计划项目(201538)~~

摘　　要：目的观察牛奶蛋白过敏患儿外周血Th17、Treg细胞及相关因子的水平,探讨玉屏风颗粒在调节患儿Th17/Treg失衡及改善临床症状的作用。方法将40例牛奶蛋白过敏患儿按随机数字表法分为常规治疗组20例和玉屏风颗粒组20例,另选取正常儿童组10例作对照。常规治疗组常规治疗2个月,玉屏风颗粒组在常规治疗的基础上加服玉屏风颗粒治疗。检测患儿血清Th17、Treg细胞数及IL-17、转化生长因子β1(TGF-β1)水平,记录患儿皮疹的湿疹面积及严重度指数(EASI)评分。结果与正常儿童组相比,过敏患儿Th17细胞数及IL-17水平明显增高(P<0.05),Treg细胞数及TGF-β1水平明显下降(P<0.05)。治疗后常规治疗组和玉屏风颗粒组Th17细胞数、IL-17水平及EASI评分均明显下降(P<0.05),Treg细胞数、TGF-β1水平较前明显上升(P<0.05);且玉屏风颗粒组与常规治疗组比较Treg细胞数、TGF-β1上升、Th17、IL-17、EASI下降更明显(均P<0.05)。结论牛奶蛋白过敏患儿体内存在明显Th17/Treg失衡。玉屏风颗粒可以调控Th17/Treg失衡,协同治疗牛奶蛋白过敏,缓解过敏症状。ObjectiveTo observe Th17 cells, Treg cells and their related factors in peripheral blood of children with milk protein allergy and explore the influence of Yupingfeng granule on Th17 / Treg imbalance and its clinical effect.Methods40 children with milk protein allergy were divided into two groups randomly： the conventional treatment group （n=20）, Yupingfeng granule group （n=20）. The conventional treatment group received conventional treatment for 2 months. On the basis of routine treatment, Yupingfeng granule group was additionally treated with Yuping feng granule. The serum Th17, Treg cell counts, interleukin （IL）-17 and transforming growth factor-β1 （TGF-β1） levels were detected, and the eczema area and severity index （EASI） score of rash in children was recorded.ResultsThe levels of Th17 cells and IL-17 in allergy children were obviously increased compared with those of the normal children, while the Treg cells, and the TGF-β1 level were lower than those of the normal children （P〈0.05）. After treatment, the Th17 cells, the IL-17 levels and ESAI scores of the conventional treatment group and the Yupingfeng granule group were lowered, while the Treg cells and the TGF-β1 levels were increased （P〈0.05）. Compared with the conventional treatment group, these indexes increased and decreased more significantly in the Yupingfeng granule group （P〈0.05）.ConclusionsMilk allergy children have obvious imbalance of Th17/Treg; the Yupingfeng granule can adjust this imbalance and alleviate the allergic symptoms of milk protein.

关 键 词：乳蛋白质类 副作用 乳类过敏反应 药物疗法 玉屏风散 治疗应用 TH17细胞 免疫学 T淋巴细胞 调节 免疫学 儿童 

分 类 号：R272[医药卫生—中医儿科学]