百令胶囊联合辛伐他汀治疗糖尿病肾病  

Corbrin capsule combined with simvastatin in the treatment of diabetic nephropathy

作　　者：扈瑞春[1] 徐国庆[2] 任彦芳 张锐莹 景鑫 汤海波[1] 李玉伶[1] 陈秋月[1] HU Rui-chun;XU Guo-qing;REN Yan-fang;ZHANG Rui-ying;JING Xin;TANG Hai-bo;LI Yu-ling;CHEN Qiu-yue(Department of Nephrology,The People＇s Hospital of Langfang City,Langfang,Hebei 065000,China)

机构地区：[1]廊坊市人民医院肾内科,河北廊坊065000 [2]廊坊市人民医院门诊办公室,河北廊坊065000

出　　处：《中国临床研究》2018年第8期1109-1113,共5页Chinese Journal of Clinical Research

基　　金：河北省廊坊市科技支撑计划项目(2014013039)

摘　　要：目的探讨百令胶囊联合辛伐他汀对糖尿病肾病患者的临床疗效、超敏C反应蛋白(hs-CRP)、肾功能及血脂水平的影响。方法选取2015年7月至2017年7月收治的210例糖尿病肾病患者,按照随机数字表法均分为三组:对照组70例,给予常规治疗;辛伐他汀组70例,在对照组基础上给予辛伐他汀治疗;联合治疗组70例,在辛伐他汀组基础上给予百令胶囊治疗。治疗3个月后,观察比较三组患者的总有效率、24 h尿蛋白定量(24h UTP)、hs-CRP、肾功能、血脂及药物不良反应等。结果治疗3个月后,三组总有效率比较差异有统计学意义(P<0.01),且联合治疗组总有效率优于对照组(91.4%vs 67.1%,P<0.017)。治疗后三组24h UTP、hs-CRP水平均低于治疗前(P<0.05);且在治疗1、2、3个月时,三组24h UTP、hs-CRP水平比较均有统计学差异(P<0.01),联合治疗组低于辛伐他汀组和对照组,辛伐他汀组又低于对照组。治疗3个月后,三组患者血肌酐、尿素氮、总胆固醇、甘油三酯及低密度脂蛋白胆固醇等均较治疗前明显降低(P均<0.05),且三组比较有统计学差异(P<0.01),联合治疗组低于辛伐他汀组和对照组,辛伐他汀组又低于对照组。三组不良反应总发生率差异无统计学意义(P>0.05)。结论百令胶囊联合辛伐他汀治疗糖尿病肾病患者疗效显著,可明显改善肾功能、血脂水平,降低炎症反应,且安全可靠。Objective To investigate the influence of Corbrin capsule combined with simvastatin on clinical efficacy,level of high-sensitivity C-reactive protein（hs-CRP）,renal function and blood lipoids in the treatment of diabetic nephropathy（DN）. Methods A total of 210 DN patients received treatment from July 2015 to July 2017 were divided into control group（regular treatment）,simvastatin group（regular treatment plus simvastatin） and combined treatment group（regular treatment plus simvastatin and Corbrin capsule） according to random number table method（n = 70 each）. After the treatment for 3 months,the total efficacy,24-hour urinary protein measurement,hs-CRP,renal function,blood lipoids and adverse drug reaction were observed and compared between three groups. Results After the treatment for 3 months,total efficacy rate of the three groups was significant different（P〈0. 01）,and the total efficacy rate in combined treatment group was significant higher than that in control group（91. 4% vs 67. 1%,P〈0. 017）. After the treatment,the level of 24-hour urinary protein and hs-CRP were lower than those before the treatment in 3 groups（P〈0. 05）,and there were significant difference between 3 groups at 1-,2-,3-month（s） after the treatment in the level of 24-hour urinary protein and hs-CRP（P〈0. 01）,and they were lowest in combined treatment group and highest in control group. After 3 months of treatment,the blood creatinine,urea nitrogen,total cholesterol,triglyceride and low density lipoprotein cholesterol in the three groups were significantly lower than those before the treatment（all P〈0. 05）,and there were significant difference between 3 groups（P〈0. 01）,and they were lowest in combined treatment group and highest in control group. There was no significant difference between 3 groups in total incidence rate of adverse reaction（P〉0. 05）. Conclusions Corbrin capsule combined with simvastatin has a significant effect in the treatment of diabetic nephropathy,which

关 键 词：糖尿病肾病 百令胶囊 辛伐他汀 24H尿蛋白定量 超敏C反应蛋白 肾功能 血脂 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]