“从脾论治”法对冠心病稳定型心绞痛患者生存质量的影响  

Effect of Treating Stable Angina Pectoris from Spleen on Quality of Life in Patients

作　　者：孔德昭[1] 张哲[2] 王洋[2] 刘悦[2] 孟繁丽 高晓宇[2] 潘家祥 唐晶 杨关林[1] KONG Dezhao;ZHANG Zhe;WANG Yang;LIU Yue;MENG Fanli;GAO Xiaoyu;PAN Jiaxiang;TANG Jing;YANG Guanlin(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学第一临床学院,辽宁沈阳110032 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2018年第7期1345-1350,共6页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(2013CB531704)

摘　　要：目的：探索＂从脾论治＂法治疗冠心病稳定型心绞痛患者的临床疗效和对冠心病心绞痛患者生存质量的影响。方法：选取2013年6月—2014年12月由国内6家中医院招募的240例冠心病稳定型心绞痛患者。随机分为对照组与＂益气健脾和血祛痰组＂和＂益气健脾祛痰化瘀组＂,每组各80例。对照组给予常规冠心病基础治疗,治疗组分别给予基础治疗联合益气健脾和血祛痰方或者益气健脾祛痰化瘀方。比较3组患者的心绞痛疗效和生活质量改善情况,并记录受试者不良反应发生情况。结果：益气健脾和血祛痰组心绞痛有效率为74.4%,益气健脾祛痰化瘀组心绞痛有效率为74.7%,高于对照组的56.9%,差异有统计学意义。心绞痛Ⅱ级患者和既往高血脂病史患者两个试验组的心绞痛有效率均高于对照组（P〈0.05）。两个试验组的西雅图心绞痛量表躯体受限维度改善情况均高于对照组;且心绞痛积分得分均低于对照组,差异具有统计学意义（P〈0.05）。两个试验组中医证候计分表总分、主证积分、次证积分与试验组比较无统计学差异。益气健脾和血祛痰组肢体沉重症状消失率显著高于对照组;益气健脾和血祛痰组对脘痞症状改善显著高于益气健脾祛痰化瘀组。受试者均未出现不良反应。结论：＂从脾论治＂法联合常规基础治疗对冠心病稳定型心绞痛的疗效显著,在有效改善心绞痛症状的同时能够提高患者的生存质量。Objective：To explore the clinical effect and quality of life improvement of the therapy＂treating angina pectoris from the spleen＂. Methods：A total of 240 patients with stable angina pectoris were recruited from 6 Chinese medicine hospitals from June 2013 to December 2014. Participants were randomly divided into the control group,Yiqi Jianpi Hexue Qutan group and Yiqi Jianpi Qutan Huayu group,each group 80 cases. The control group was given the basic treatment of conventional coronary heart disease,while the treatment groups were given basic treatment combined with Yiqi Jianpi Hexue Qutan Prescription and Yiqi Jianpi Qutan Huayu Prescription respectively. The efficacy and quality of life of angina pectoris patients were compared among the three groups and the adverse events were recorded. Results：The effective rate of angina pectoris in Yiqi Jianpi Hexue Qutan group was 74. 4% and that of Yiqi Jianpi Qutan Huayu group was 72. 7%,which were higher than that of the control group（ P〈0. 05）.The effective rate of angina pectoris was higher in patients with angina pectoris grade Ⅱ and previous patients with hyperlipidemia than that in the control group（ P〈0. 05）. The improvement of somatosensory dimension of the Seattle Heart Syndrome Scale in the two test groups was higher than that in the control group. The scores of angina pectoris were lower than those of the control group（P 0. 05）. There were no significant differences in the scores of TCM syndromes between the two test groups. The exacerbation rate of the symptoms of limb heavy in Yiqi Jianpi Hexue Qutan group was significantly higher than that of the control group. The symptoms of abdominal fullness in Yiqi Jianpi Hexue Qutan group was significantly higher than that of Yiqi Jianpi Qutan Huayu group. Subjects did not show any adverse reactions. Conclusion：The combination therapy of ＂spleen treatment＂and conventional basal therapy has a significant effect on the stable angina pectoris of coronary heart disease,and can improve the q

关 键 词：冠心病 从脾论治 生存质量 

分 类 号：R541.4[医药卫生—心血管疾病]