电针对膝关节骨性关节炎的疗效以及对骨性关节炎患者血浆CXCL10、IL-1β含量的影响  

Curative Effect of Electroacupuncture Treating Knee Osteoarthritis and Its Effect on Plasma CXCL10 and IL-1β

作　　者：张婷[1] 马朝阳[2] 李熳[3] 焦群茹 余丹[5] 贾珉[5] 苑小翠 吕正涛 ZHANG Ting;MA Chaoyang;LI Man;JIAO Qunru;YU Dan;JIA Min;YUAN Xiaocui;LYU Zhengtao(Renhe Hospital Affiliated to the Three Gorges University,Yichang 443000,Hubei,China;Central Hospital of Wuhan,Wuhan 430000,Hubei,China;College of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China;Wuhan Fifth Hospital,Wuhan 430021,Hubei,China;The First People＇s Hospital of Wuhan,Wuhan 430022,Hubei,China;Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)

机构地区：[1]三峡大学附属仁和医院,湖北宜昌443001 [2]武汉市中心医院,湖北武汉430000 [3]华中科技大学同济医学院基础医学院,湖北武汉430030 [4]武汉市第五医院,湖北武汉430021 [5]武汉市第一医院,湖北武汉430022 [6]华中科技大学同济医院骨科,湖北武汉430030

出　　处：《辽宁中医杂志》2018年第7期1469-1472,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81473768)

摘　　要：目的：观察电针治疗膝骨关节炎的临床疗效及其对KOA患者血浆CXCL10及IL-1β浓度的影响。方法：将39名KOA患者均采用电针疗法,每天电针1次,6次为一个疗程,一共治疗2个疗程,疗程间休息1天。分析比较治疗前后WOMAC、NRS评分及患者血浆CXCL10、IL-1β含量。结果：（1）电针治疗前与治疗后比较,WOMAC、NRS评分均有统计学意义（P〈0.05）;（2）电针治疗后患者血浆CXCL10含量升高,具有统计学意义（P〈0.05）;（3）电针治疗后患者血浆IL-1β含量降低,与治疗前比较,具有显著性差异（P〈0.05）。结论：电针疗法能有效地缓解KOA患者的临床症状,特别是在镇痛方面。Objective：To observe the clinical effect of electroacupuncture on knee osteoarthritis and its effect on plasma concentrations of CXCL10 and IL-1β in patients ith KOA. Methods：Thirty-nine KOA patients were treated with electroacupuncture,once a day,a course of 6 times,a total of 2 treatment courses. There was a rest for 1 day between two courses. The WOMAC,NRS score and plasma levels of CXCL10 and IL-1 β were measured and analyzed before and after treatment. Results：（1） Compared with baseline,both WOMAC score and NRS score reduced significantly after two courses＇ treatment（ P〈0.05）.（2） Plasma levels of CXCL10 significantly increased after EA treatment（ P〈0.05）.（3） Plasma levels of IL-1β decreased significantly after EA treatment（ P〈0.05）. Conclusion：Electroacupuncture therapy can effectively relieve the clinical symptoms of the KOA patients,especially in pain relief.

关 键 词：电针 KOA CXCL10 IL-1Β WOMAC NRS 

分 类 号：R245.97[医药卫生—针灸推拿学] R684.3[医药卫生—中医临床基础]