巨噬细胞自噬与动脉粥样硬化相关性研究进展  

Relationship between macrophage autophagy and atherosclerosis:research advances

作　　者：宋东清[1] 马莉[1] SONG Dong-qing;MA Li(General Hospital ofPLA Guangzhou Military Area,Guangzhou 510080,China)

机构地区：[1]广州军区广州总医院,广州510080

出　　处：《国际药学研究杂志》2018年第4期263-266,共4页Journal of International Pharmaceutical Research

基　　金：广东省自然科学基金资助项目(2016A030313755)

摘　　要：巨噬细胞是动脉粥样硬化(AS)斑块形成和发展的重要参与者,巨噬细胞自噬作为AS新的参与者已得到越来越多学者关注。自噬是由溶酶体系统降解细胞内受损、变性、衰老的蛋白质与细胞器的过程,基础自噬可保护细胞免受环境刺激影响,而过度自噬则导致细胞死亡,通过调控巨噬细胞自噬可影响动脉粥样硬化发生发展。本文就AS发展过程中调控巨噬细胞自噬信号通路、诱导自噬的影响因素等进行系统阐述,为AS的治疗提供新的靶点。Macrophage plays important roles in the formation of atherosclerotic plaque,and the role of macrophage autophagy in the process of atherosclerosis has drawn increasing attention from researchers. The lysosomal system degrades damages,degenerated,senescent organelles and proteins in the cytoplasm. Basic level of autophagy can protect the cells from environmental stimuli,while excessive autophagy can lead to cell death and do harm to the stability of the plaque. The regulation of macrophage autophagy can affect the development of atherosclerosis. In this paper,the regulation of macrophage signal pathway in the development of atherosclerosis,the factors that induce autophagy and other factors are reviewed systematically in order to provide a new target for the treatment of atherosclerosis.

关 键 词：巨噬细胞 动脉粥样硬化 细胞自噬 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R54[医药卫生—基础医学]