1,5-脱水葡萄糖醇检测对短期血糖水平预测及临床新应用研究  

1,5-Anhydroglucitol as Short-term Glycemic Markers and Usage in Other Clinical Fields

作　　者：林敏 郑华 陈丽萌[1] LIN Min;ZHENG Hua;CHEN Li-meng(Department of Nephrology,Peking Union Medical College Hospital,Chinese Medical Science Academy,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院肾内科,北京100730

出　　处：《现代检验医学杂志》2018年第4期1-3,7,共4页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金(81470937;81641024);国家重点研发计划"精准医学"重点专项(2016YFC0901500);宁夏回族自治区重点研发计划(对外科技合作专项)东西部合作项目(2018YBZD0557);中国医学科学院医学与健康科技创新工程经费资助(2016-12M-2-004);中国医学科学院协和学者基金;北京协和医学院教学改革基金(2016zlgc0103)

摘　　要：1,5-脱水葡萄糖醇(1,5-anhydroglucitol,1,5-AG)是人体内广泛存在且化学性质稳定的单糖,其浓度在血糖正常时稳定,当血糖超过肾糖阈时降低,可用于监测短期血糖水平变化。近年来研究表明1,5-AG不仅可以增加早期糖尿病诊断的敏感度和特异度、监测妊娠期血糖波动和新生儿相关并发症;在评估糖尿病相关微血管病变,预测心脑血管不良事件等方面也具有独特优势,此外它还直接参与血糖调节和炎症反应,是有较好临床应用前景的生物标志物。1,5-anhydroglucitol（1,5-AG）is a chemically inert monosaccharide widely distributed in the human body,whose concentration is stable under normal serum glucose level but declines when serum glucose level exceeds the renal glucose threshold.1,5-AG can reflect short-term glycemic control,especially serum glucose fluctuation and postprandial hyperglycemia.1,5-AG also shows superior sensitivity and specificity in early diagnosis of diabetes and notable value in gestational diabetes mellitus,neonatal complications,diabetes-related microangiopathy monitor,and cardiovascular and cerebrovascular adverse event prediction.In addition,1,5-AG directly participates in glucose metabolism and inflammatory reactions.In conclusion,1,5-AG has been proved as a promising clinical and academic biomarker.

关 键 词：1 5-脱水葡萄糖醇 血糖波动 微血管病变 心脑血管事件 

分 类 号：R446.12[医药卫生—诊断学]