非甲状腺疾病患者血清T3(FT3),T4(FT4)和sTSH水平同时下降的结果探讨  

Discussion on Simultaneous Decrease of the Level of Serum T3(F3),T4(FT4) and sTSH in Non-Thyroid Patients

作　　者：戴晓灵 应红灵 DAI Xiao-ling;YING Hong-ling(Department of Clinical Laborator;Advanced Student,People＇s Hospital of Wanzhou District in Chongqing,Chongqing 404000,China)

机构地区：[1]重庆市万州区人民医院检验科,重庆404000 [2]重庆市万州区人民医院,重庆404000

出　　处：《现代检验医学杂志》2018年第4期144-145,148,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨临床上部分非甲状腺疾病患者在无抗甲状腺药物治疗情况下,患者血清三碘甲状腺原氨酸(triiodothyronine,T3)、游离三碘甲状腺原氨酸(tree triiodothyronine,FT3)、甲状腺激素(thyroid hormone,T4)、游离甲状腺素(tree thyroxine,FT4)和超敏促甲状腺素(thyroid stimulating hormone,sTSH)水平同时下降的影响因素。方法收集2016年1~12月在重庆市万州区人民医院住院期间的非甲状腺疾病患者172例作为观察组,并选择同期体检的健康者135例作为对照组,以化学发学法检测T3,FT3,T4,FT4及sTSH血清水平,两样本均数的比较采用t检验,比较两组的水平差异。结果观察组与对照组比较,血清T3:0.68±0.25nmol/L vs 1.63±0.32nmol/L,FT3:2.77±0.45pmol/L vs 4.71±0.77pmol/L,T4:43.54±10.9nmol/L vs 107.82±21.91nmol/L,FT4:9.23±1.81pmol/L vs 17.24±2.27pmol/L和sTSH:0.150±0.144mIU/L vs 2.253±1.25mIU/L,其值均低于健康对照组,差异均有统计学意义(t=9.433 8~16.7218,均P<0.01)。结论非甲状腺疾病患者,血清T3(FT3),T4(FT4)及sTSH水平同时降低,是患者危重的一种机体代谢调节与自我保护,对临床甲状腺疾病的鉴别诊断及预后判断有重要意义。Objective To investigate the serum triiodothyronine（T3）and free triiodoronthyine（FT3）in some clinical patients with non-thyroid diseases without anti-thyroid medication,thyroid hormone（T4）and free thyroxine（FT4）and allergic to promote thyroxine（thyroid stimulating hormone,sTSH）level and the influence factors of decline.Methods Collected172 patients with thyroid diseases in Wanzhou District People＇s Hospital of Chongqing from January 2016 to December 2016 as observation group,and selected 135 cases of healthy subjects as control group in the same period.Their serum levels of T3,FT3,T4,FT4 and sTSH were detected with chemiluminescent method.The t test was used for comparison of two sample mean,comparing their differences.Results Comparison between the observation group and the control group,serum T3：0.68± 0.25 nmol/L vs 1.63±0.32 nmol/L,FT3：2.77±0.45 pmol/L vs 4.71±0.77 pmol/L,T4：43.54±10.9 nmol/L vs 107.82±21.91 nmol/L,FT4：9.23±1.81 pmol/L vs 17.24±2.27 pmol/L,and sTSH：0.150±0.144 mIU/L vs 2.253±1.25 mIU/L,both of which were lower than the healthy control group,with statistically significant differences（t=9.4338-16.721 8,all P〈0.01）.Conclusion The thyroid disease patients,serum T3（FT3）,T4（FT4）and the level of sTSH reduced at the same time,is a kind of critically ill patients with the body＇s metabolic regulation and self protection,for the differential diagnosis and prognosis of thyroid disease clinical judgement is important.

关 键 词：非甲状腺疾病 甲状腺激素 促甲状腺激素 

分 类 号：R581[医药卫生—内分泌] R392.11[医药卫生—内科学]