妊娠合并甲状腺功能减退症与早期自然流产及不良妊娠结局的关系探讨  

Relationship between pregnancy with hypothyroidism and early spontaneous abortion and adverse pregnancy outcomes

作　　者：林丹[1] 金松[1] 陈蔚[1] LIN Dan;JIN Song;CHEN Wei(Department of Obstetrics,The First Affiliated Hospital of Hainan Medical College,Haikou 570100,China.)

机构地区：[1]海南医学院第一附属医院产科,海口570100

出　　处：《妇产与遗传（电子版）》2018年第2期9-13,共5页Obstetrics-Gynecology and Genetics (Electronic Edition)

摘　　要：目的探讨妊娠合并甲状腺功能减退症与早期自然流产及不良妊娠结局的关系。方法选取2012年4月至2017年7月因先兆流产就诊于海南医学院第一附属医院并且追访到妊娠结局的133名患者作为研究对象,其中甲状腺功能减退症患者(33例)设为观察组,甲状腺功能正常的患者(100例)设为对照组,比较两组患者的妊娠结局,分析甲状腺功能减退与早期自然流产及不良妊娠结局的关系。结果观察组早期自然流产率(18.18%)、早产率(27.27%),明显高于对照组(8.00%、8.00%),两组比较,差异有统计学意义(P<0.05),观察组足月分娩率(51.52%)明显低于对照组(82.00%),两组比较,差异有统计学意义(P<0.05);分析两组不良妊娠结局,观察组易栓症、低出生体质量儿发生率(27.27%、15.15%)明显高于对照组(4.00%、2.00%),两组比较,差异有统计学意义(P<0.05);观察组剖宫产率高于对照组(36.36%vs 35.00%),顺产率低于对照组(42.42%vs 55.00%),两组比较,差异无统计学意义(P>0.05)。结论甲状腺功能减退易导致早期自然流产,增加产科并发症的发生风险,早期诊断与及时治疗可以有效地减少妊娠并发症的发生,从而改善妊娠结局。Objective To investigate the relationship between pregnancy with hypothyroidism and early spontaneous abortion and adverse pregnancy outcomes. Methods 133 patients who were diagnosed as threatened abortion and hospitalized at the First Affiliated Hospital of Hainan Medical College with pregnancy outcome follow-up were selected as the study subjects, 33 patients with hypothyroidism were set as the observation group,and 100 patients with normal thyroid function were set as the control group, The pregnancy outcomes of the two groups were compared and analyzed the relationship between pregnancy with hypothyroidism and early spontaneous abortion and adverse pregnancy outcomes. Results The early spontaneous abortion rate（ 18. 18%） and premature birth rate（ 27. 27%） in the observation group was significantly higher than that in the control group（ 8. 00%,8. 00%）,and the differences were statistically significant（ P〈 0. 05）. The term delivery rate in theobservation group（ 51. 52%） was significantly lower than that in the control group（ 82. 00%）,there was a statistically significant difference between the two groups（ P〈 0. 05）. The analysis of adverse pregnancy outcomes in the two groups showed that the incidence of thrombophilia and low birth weight infants in the observation group（ 27. 27%,15. 15%） were significantly higher than that in the control group（ 4. 00%,2. 00%）,and the differences were statistically significant（ P〈 0. 05）. The cesarean section rate in the observation group was higher than in the control group（ 36. 36% vs 35. 00%）,and the normal labor rate in the observation group was lower than in the control group（ 42. 42% vs 55. 00）,and the differences were statistically significant（ P〉 0. 05）. Conclusions Hypothyroidism can easily lead to early spontaneous abortion and increase the risk of obstetric complications. Early diagnosis and timely treatment can effectively reduce the occurrence of pregnancy complications and improve pregnancy outcomes.

关 键 词：甲状腺功能减退症 流产 自然 不良妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]