骨骼和睾丸的信号交流及其临床意义  

Signal communication between bone and testis and its clinical significance

作　　者：李雨珏 余希杰[1] Li Yujue;Yu Xijie(Department of Endocrinology and Metabolism,Laboratory of Endocrinology and Metabolism,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院内分泌代谢科,内分泌与代谢病研究室,成都610041

出　　处：《中华内分泌代谢杂志》2018年第8期712-716,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（81370969、81572639、81770875）

摘　　要：雄激素不仅在生殖功能方面起到至关重要的作用，对维持骨骼的生长和保证骨骼的完整性也具有重要意义。传统观点认为骨骼仅仅是接受激素调节的靶器官。然而，近年来的研究发现，骨骼自身也可作为内分泌器官调控睾丸功能。本文将介绍睾丸在骨代谢中的影响以及骨骼对睾丸的反向调节作用，并初步探讨其临床意义。Androgen plays vital roles not only in reproductive function, but also in maintaining bone growth and in ensuring bone integrity. Traditionally, bone is nothing but a hormone-regulated organ. However, recent studies have shown that bone can also act as an endocrine organ to regulate the function of testis. In this review, we introduce the function of testis in bone metabolism, the role of bone on the regulation of testis, as well as explore related clinical significance.

关 键 词：骨骼 睾丸 睾丸间质细胞 

分 类 号：R335[医药卫生—人体生理学]