门静脉高压症大鼠脾脏大小与脾功能亢进关系的初步研究  

The relationship between sizes of spleen and hypersplenism in rats with portal hypertension

作　　者：杨军 李向农 YANG Jun,LI Xiangnong(Department of General Surgery,the Affiliated Hospital of Xuzhou MedicalUniversity,Xuzhou,Jiangsu 221002,China)

机构地区：[1]徐州医科大学附属医院普通外科,江苏徐州221002

出　　处：《检验医学与临床》2018年第17期2557-2558,2563,共3页Laboratory Medicine and Clinic

摘　　要：目的观察门静脉高压症大鼠脾脏大小与脾功能亢进的相关性,评价肝功能对脾功能亢进的影响。方法 28只雄性SD大鼠分3组,A、B组各10只分别建立大鼠肝硬化模型和门静脉缩窄模型,C组8只为正常对照组。观察各组大鼠肝组织学变化,测量门静脉压、脾髓压、脾质量,计算脾脏指数,检测外周血肝功能及血常规。结果 A、B组脾脏指数、门静脉压、脾髓压较C组高(P<0.05),A组血小板较另外2组低(P<0.05)。各组脾脏指数与血小板减少之间无直线相关关系。结论脾肿大与血细胞计数减少之间无明显的相关关系,肝功能可能对血液系统改变有一定作用。Objective To study the relationship between sizes of spleen and peripheral blood cell counts,and to evaluate effects of the liver function upon hypersplenism in rats with portal hypertension induced by cirrhosis or partial portal vein ligation. Methods A total of 28 male SD rats were divided into three groups.Group A （ n =10） and group B （ n =10） were used for establishment of portal hypertensive models through cirrhosis-induction and partial portal vein ligation respectively.Group C （ n =8） served as controls.Changes in liver histology,portal venous pressure,splenic pulp pressure,calculated spleen index （SI）,liver function and peripheral blood cell counts were observed. Results The values of SI,portal vein pressure and splenic pulp pressure were significantly higher in groups A and B than that in group C（ P 〈0.05）,with a lower platelet count in group A compared to other two groups（ P 〈0.05）.There was no linear relationship observed between SI and the reduction of platelet count in all of the three groups. Conclusion There was no obvious relationship between splenic sizes and platelet counts in portal hypertensive rats with cirrhosis or partial portal vein ligation.However,liver function may play a role in changes of peripheral blood cell counts.

关 键 词：肝硬化 门静脉高压症 脾脏指数 

分 类 号：R604[医药卫生—外科学]