黄连素联合苯溴马隆治疗高尿酸血症伴痛风的疗效与安全性  

Efficacy and safety of Berberine combined with Benzbromarone in the treatment of hyperuricemia with gout

作　　者：王洋[1] 杨榕[1] 单玲[1] 袁景 WANG Yang;YANG Rong;SHAN Ling(Department of Endocrinolopy,The People＇ s Hospital of China Medical University ＆ The People＇ s Hospital of Liaoning Province,Shenyang 110016,China)

机构地区：[1]中国医科大学人民医院、辽宁省人民医院内分泌科,110016

出　　处：《中国现代药物应用》2018年第17期3-6,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探索黄连素联合苯溴马隆治疗高尿酸血症伴痛风的疗效和安全性,及对炎症因子的影响。方法 58例高尿酸血症伴痛风患者作为研究对象,随机分为试验组(使用黄连素+苯溴马隆治疗)和对照组(使用苯溴马隆治疗),各29例。治疗12周后观察比较两组患者血尿酸(SUA)、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹胰岛素(FINS)、谷丙转氨酶(ALT)、肌酐(Cr)水平及炎症因子超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、白细胞介素-18(IL-18)水平变化。比较两组胰岛素抵抗指数(HOMA-IR)。结果经过12周治疗,两组患者SUA水平与治疗前比较均有明显下降,差异具有有统计学意义(P<0.05);试验组较对照组下降明显,差异统计学意义(P<0.05)。两组FPG均较治疗前有所下降,但差异无统计学意义(P>0.05)。试验组治疗后TG、TC、LDL-C较治疗前均有明显下降,差异具有统计学意义(P<0.05);治疗后试验组HDL-C较治疗前升高,差异有统计学意义(P<0.05)。试验组治疗后TG、TC、HDL-C、LDL-C均优于对照组治疗后,差异具有统计学意义(t=20.91,19.84,3.30,9.08,P<0.05)。试验组治疗后FINS水平及HOMA-IR指数均低于对照组,差异具有统计学意义(P<0.05)。治疗后试验组hs-CRP、IL-18、IL-1β较治疗前均明显下降,差异具有统计学意义(P<0.05),治疗后对照组较治疗前比较水平有所下降,差异无统计学意义(P>0.05),试验组各项指标均优于对照组,差异具有统计学意义(Z=4.26,6.12,5.23,P<0.05)。治疗后试验组无明显不良反应发生,发生率为0(0/29);对照组有5例患者治疗过程中诱发急性痛风发作,发生率为17%(5/29),两组比较差异具有统计学意义(χ2=5.47,P<0.05)。结论黄连素联合苯溴马隆能够有效降低高尿酸血症伴痛风的尿酸水平,且有效改善代谢紊乱及炎症状态。Objective To explore the clinical efficacy and safety of Berberine combined with Benzbromarone in the treatment of hyperuricemia with gout and their effects on inflammatory factors. Methods A total of 58 hyperuricemia with gout patients were selected as research objects, they were randomly divided into experimental group and control group, 29 cases in each group. The experimental group was given Berberine combined with Benzbromarone for treatment, the control group was given Benzbromarone alone. After 12 weeks of treatment, the levels of serum uric acid（SUA）, fasting blood glucose（FBG）, triglyceride（TG）, total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C）, fasting insulin（FINS）, alanine transaminase（ALT）, creatinine（Cr）, the changes of inflammatory factor hypersensitivity C reactive protein（hs-CRP）, interleukin-1β（IL-1β） and interleukin-18（IL-18） levels and the homeostasis model assessment of insulin resistance（HOMA-IR） between the two groups were observed and compared. Results After 12 weeks of treatment, the levels of SUA in the two groups were significantly lower than those before treatment, the differenceswere statistically significant（P〈0.05）, the experimental group decreased significantly compared with the control group, the difference was statistically significant（P〈0.05）. The FPG of two groups after treatment were lower than before treatment, but the differences were not statistically significant（P〉0.05）. After treatment, the TG, TC and LDL-C of the experimental group after treatment decreased significantly compared with those before treatment, the differences were statistically significant（P〈0.05）. And the HDL-C in the experimental group after treatment was significantly higher than that before treatment, the difference was statistically significant（P〈0.05）. After treatment, TG, TC, HDL-C and LDL-C in the experimental group were significantly better than those in

关 键 词：高尿酸血症 黄连素 苯溴马隆 痛风 疗效 安全性 炎症因子 

分 类 号：R589.7[医药卫生—内分泌]