临床患者红细胞血型同种不规则抗体的回顾性分析  

Retrospective analysis of the incidence irregular antibodies of RBC blood type in the patients

作　　者：张趁利 庞桂芝 娄白敏 鲍瑞玲[2] 赵凤莲[3] Zhang Chenli;Pang Guizhi;Lou Baimin;Bao Ruiling;Zhao Fenglian(Xinxiang Blood Station,Xinxiang 453000,China;Xinxiang Center Hospital,Xinxiang 453000,China;Xinxiang People ＇ s Hospital,Xinxiang 453000,China)

机构地区：[1]新乡市中心血站,河南新乡453000 [2]新乡市中心医院,河南新乡453000 [3]新乡市第一人民医院,河南新乡453000

出　　处：《河南医学研究》2018年第15期2700-2702,共3页Henan Medical Research

基　　金：新乡市科学发展计划基金资助项目(05S003)

摘　　要：目的调查临床患者红细胞血型同种不规则抗体的分布情况,分析不规则抗体产生的原因及临床意义。方法回顾性分析2014年1月至2017年12月新乡地区临床医院送检临床患者的不规则抗体情况,对不规则抗体筛选阳性标本进行抗体鉴定并分类,并统计分析相关资料。结果 2014年1月至2017年12月临床医院送检患者中检出不规则抗体95例,抗体特异性为抗-E12例(12.63%),抗-Ec19例(20.00%),抗-D10例(10.52%),抗-Ce2例(2.11%),抗-DC6例(10.53%),抗-JKa2例(2.11%),抗-M12例(12.63%),冷抗体10例(10.53%),不明特异性抗体20例(21.05%),抗-P12例(2.11%)。女性患者不规则抗体总体检出率高于男性(P<0.01),有输血史、妊娠史患者的检出率高于无输血史和妊娠史的患者(P<0.05)。结论住院患者输血前应全面开展红细胞不规则抗体筛检,尤其是对有输血史、妊娠史的患者具有重要意义,可有效避免临床患者免疫性溶血反应的发生,减少输血风险,确保临床输血安全、有效。Objective To conduct a retrospective analysis of irregular antibodies on red blood group in the patients to explore the cause and the clinical significance of irregular antibodies.Methods A retrospective analysis of the irregular antibody status of clinical patients in hospitals in Xinxiang area from January of 2014 to December of 2017 was analyzed. Antibody identification and classification of irregular antibody screening positive specimens were carried out, and relevant data were analyzed .Results A total of 95 antibodies were detected in clinical patients. 12 cases of Anti-E was the most common and specific antibody（12.63%）, 19 cases of anti-Ec（20.00%）, 10 cases of anti-D（10.52%）, 2 cases of anti-Ce（2.11%）, 12 cases of anti-M （12.63%）, 6 cases of anti-DC（10.53%）, 2 cases of anti-JK a（2.11%）, 12 cases of anti-M（12.63%）, 10 cases of cold antibody（10.53%）, 20 cases of antibodies of undetermined specificity （21.05%）, 2 cases of anti-P 1（2.11%）. The frequently of irregular antibodies in female was shown to be higher than male patients（ P 〈0.01）, and was also found to be higher in people with pregnancy or transfusion history（ P 〈0.05）.Conclusion Irrgular antibody screening and identification of red blood cells should be carried out in a comprehensive way are very important before blood transfusion, especially with transfusion history or pregnancy. In order to avoid the occurrence of immunological hemolysis reaction in clinical patients, reducing the risk of blood transfusion, and ensure the safety of blood transfusion.

关 键 词：红细胞血型 不规则抗体 抗体筛检 抗体特异性 输血安全 

分 类 号：R457.1[医药卫生—治疗学]