黄精舒眠颗粒提取及成型工艺优选研究  

Optimization of extraction and shaping technology of Huangjing Shumian granules

作　　者：吴静澜[1] 赵罗娜[1] 张永萍[1] 陈汝玲 郭璐玫 黄吉东 周永芝 杨荣熙 WU Jinglan;ZHAO Luona;ZHANG Yongping;CHEN Ruling;GUO Lumei;HUANG Jidong;ZHOU Yongzhi;YANG Rongxi(Guiyang University of Chinese Medicine,Guiyang 550025,China;Guizhou Institute for Drug Control,Guiyang 550004,China;Guizhou Laolaifu Pharmacy Co.Ltd.,Guiyang 550000,China)

机构地区：[1]贵阳中医学院,贵州贵阳550025 [2]贵州省药品检验所,贵州贵阳550004 [3]贵州老来福药业有限公司,贵州贵阳550000

出　　处：《贵州科学》2018年第4期16-19,共4页Guizhou Science

基　　金：贵州省中药现代化科技产业研究开发专项项目(No.黔科合SY字[2014]3009号);贵州省普通高等学校中药民族药(苗药)新剂型新制剂工程研究中心(No.黔教合KY字[2014]22号);贵州省中药(民族药)药剂学专业学位研究生工作站(No.黔教研合YJSZ字[2013]05号);贵州省现代民族药(苗药)协同创新中心(No.黔教合协同创新字[2013]02号);国家中医药管理局中药特色技术传承人才项目(国中医药办人教发[2014]39号

摘　　要：目的:优选黄精舒眠颗粒的水提取工艺和成型工艺。方法:以总固物、天麻素含量、总糖含量为考察指标,通过L_9(3~4)正交试验考察提取次数、提取时间、加水量对黄精舒眠颗粒提取工艺的影响;以粒度、堆密度、休止角、吸湿率为指标,采用单因素试验考察辅料用量对黄精舒眠颗粒成型工艺的影响。结果:优选的水提取工艺条件为煎煮3次,每次1 h,每次加10倍量水。成型工艺为提取液浓缩至相对密度约为1.30~1.35的清膏,与淀粉、糊精按1∶1∶1混合后制颗粒。结论:优选的工艺合理可行,适用黄精舒眠颗粒的制备。In this study,we optimized the extraction and shaping technology of Polygonatum sibiricum granules.With the yield of dry extraction,and the content of gastrodin and total carbohydrate as evaluation indexes,L_9（ 3~4）orthogonal experiments were carried out to evaluate the effects of extraction time,number of extraction times,and water adding level on the extraction of Polygonatum sibiricum. With the particle size,bulk density,angle of repose,and moisture content as indexes,single factor experiments were carried out to evaluate the effects of adjuvant materials on the shaping of Polygonatum sibiricum granules. As a result,the optimum extraction process was decoct extracting for 3 times（ 1 h each time） with tenfold water amount. The optimum shaping process was concentrating the solution to the relative density of 1. 30-1. 35,then mixing with starch and dextrin in ratio of 1∶ 1∶ 1 to make granules.This optimized technology was feasible,and could be used in the production of Polygonatum sibiricum granules.

关 键 词：黄精舒眠颗粒 提取工艺 成型工艺 天麻素 多糖 

分 类 号：R284.2[医药卫生—中药学] R932[医药卫生—中医学]