血清铁蛋白与红细胞参数在孕产妇缺铁性贫血中的临床应用  

The Significance of the Serum Ferritin and Red Blood Cell Parameters in Pregnant Women with Iron Deficiency Anemia

作　　者：何芳[1] 钱婷婷[1] 张国英[1] HE Fang;QIAN Ting-ting;ZHANG Guo-ying(Department of Clinical Laboratory,Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine,Nanjing 210014,China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院检验科,江苏南京210014

出　　处：《标记免疫分析与临床》2018年第8期1134-1136,1141,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨血清铁蛋白(SF)及红细胞参数在孕产妇缺铁性贫血(IDA)中的诊断价值。方法选取我院2015年1月至2016年12月缺铁性贫血的孕产妇227例作为贫血组,另取同期体检的正常孕产妇80例作为对照组。对两组孕产妇的外周血红细胞参数以及血清铁蛋白相关指标进行测定,对比分析各指标的差异。结果与正常对照组相比,贫血组的血红蛋白(HGB),红细胞平均体积(MCV),红细胞平均血红蛋白量(MCH),红细胞平均血红蛋白浓度(MCHC)以及SF均明显降低,红细胞体积分布宽度(RDW)明显升高,差异有统计学意义(P<0.05);对照组以及轻、中、重度缺铁性贫血组之间的血清SF水平有显著差异(F=609.78,P<0.05)且呈降低趋势;HGB和SF的诊断灵敏度和特异性均高于红细胞其他参数,分别是91.3%,87.7%和87.5%,91.7%。结论血清铁蛋白及红细胞参数对孕产妇IDA的诊断有重要意义,血清铁蛋白对贫血程度的诊断具有一定的价值。Objective To investigate the diagnostic value of serum ferritin（SF） and red blood cell parameters in pregnant women with iron deficiency anemia （IDA）. Methods 227 cases of iron deficiency anemia in our hospital from January 2015 to December 2016 were selected as anemia group, and other normal pregnant women in the same period were selected as control group （n = 80 ）. Maternal peripheral red blood cell parameters and serum ferritin related indexes were measured, and the differences of each index were compared between two groups. Results Compared with control group, hemoglobin （HGB）, mean corpuscular volume （ MCV ）, mean corpuscular hemoglobin （ MCH）, mean corpuscular hemoglobin concentration （MCHC） and SF in anemia group significantly decreased, and red blood cell volume distribution width （RDW）in anemia group significantly increased （ P 〈 0.05 ） ; There was significant difference in serum SF level between mild, moderate and severe iron deficiency anemia groups （ F = 609.78 ; P 〈 0.05 ） and data showed a decreasing trended HGB-and SF; the sensitivity and specificity were higher than those of other red blood cell parameters, 91.3% ,87.7% and 87.5% ,91.7%. Conclusion Serum ferritin and red blood cell parameters are of great significance in the diagnosis of IDA in pregnant women. Serum ferritin has good value in the diagnosis of anemia.

关 键 词：血清铁蛋白 红细胞参数 孕产妇 缺铁性贫血 

分 类 号：R714.254[医药卫生—妇产科学]