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作 者:曹静[1] 谢院生[1] Cao Jing;Xie Yuansheng(Department of Nephrology,Chinese PLA General Hospital,Chinese PLA Institute of Nephrology,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing 100853,China Corresponding author : Xie Yuansheng,Email :xieyuansn@ hotmail,com)
机构地区:[1]解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心,北京100853
出 处:《中华肾病研究电子杂志》2017年第2期88-91,共4页Chinese Journal of Kidney Disease Investigation(Electronic Edition)
基 金:国家重点研发计划(2016YFC0901502);国家重大科学研究计划项目(2011CB944004);北京市自然科学基金项目(7152138);国家自然科学基金项目(81473531)
摘 要:影响胎儿肾脏发育的因素很多,如母亲的营养状况、健康状态以及用药等其他因素。早产儿和出生低体重儿(LBWI)肾小球、肾小管发育不成熟,肾单位减少,未成年时期容易发生肾脏疾病,比较常见的类型包括急性肾损伤、局灶节段性肾小球硬化等。此外,早产儿和LBWI成年时期易患高血压和糖尿病,可累及肾脏。揭示早产儿和LBWI肾损害的发生发展机制,有利于早期干预及延缓肾脏病的进展。Many- factors could affect the development of fetal kidneys, such as maternal nutritional status, health, medication, and so on. Premature and low birth weight infants (LBWI) have immature glomeruli and tubules as well as reduced nephrons, and are prone to renal diseases during their minority, including acute renal injury-, focal segmental glomerular sclerosis, etc. In addition, premature infants and LBWI will be susceptible to hypertension and diabetes during their adult period, which may lead to kidney injury-. Revealing the pathogenesis and development mechanism of kidney injury- in premature infants and LBWI will be helpful for early intervention and delaying the progression of kidney diseases.
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