舒血宁对重症急性胰腺炎患者高凝状态及心脏损伤标志物的影响  

Effects of Shuxuening on hypercoagulable state and cardiac injury markers in patients with severe acute pancreatitis

作　　者：李洪[1] LI Hong(The Second People′s Hospital of Panzhihua,Sichuan 617000,China)

机构地区：[1]攀枝花市第二人民医院,四川攀枝花617000

出　　处：《国际检验医学杂志》2018年第17期2159-2162,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨舒血宁对重症急性胰腺炎(SAP)患者高凝状态及心脏损伤标志物的影响。方法选取该院2013年1月至2017年6月收治的SAP患者102例为研究对象,根据随机数字表法分为对照组(n=51)和观察组(n=51)。对照组进行常规综合治疗,观察组在对照组基础上给予舒血宁治疗。比较两组治疗临床效果,治疗前后炎症因子水平、急性生理与慢性健康评分系统(APACHEⅡ)评分、凝血相关指标以及心脏损伤相关指标变化。结果观察组治疗总有效率为94.12%,明显高于对照组(P<0.05);治疗后,观察组血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)和白介素-6(IL-6)水平分别为(49.53±12.66)ng/L、(6.49±2.08)mg/L和(22.65±12.49)pg/mL,明显低于对照组(P<0.05),观察组APACHEⅡ评分为(12.28±3.22)分,明显低于对照组(P<0.05);治疗后,观察组D-二聚体(D-D)、纤维蛋白原(FIB)水平分别为(6.25±1.14)mg/L、(2.47±0.51)g/L,明显低于对照组(P<0.05),观察组蛋白C活性为(122.74±16.38)%,明显高于对照组(P<0.05);治疗后,观察组肌钙蛋白Ⅰ(cTnⅠ)、磷酸肌酸激酶同工酶(CK-MB)和乳酸脱氢酶同工酶(LDH-1)水平分别为(0.13±0.12)ng/mL、(23.64±12.54)U/L和(52.66±19.56)U/L,明显低于对照组(P<0.05)。结论舒血宁可有效降低SAP患者机体炎症因子水平,改善血液高凝状态,保护心脏,提高治疗效果。Objective To explore the effects of Shuxuening on hypercoagulable state and cardiac injury markers in patients with severe acute pancreatitis （SAP）. Methods 102 cases of SAP patients treated in our hospital from January 2013 to June 2017 were selected for the study and divided into the control group （n=51） and the observation group （n=51） according to the random number table method.The control group was given the routine comprehensive therapy,and the observation group was given the Shuxuening on the basis of the control group.The treatment clinical effects,the changes of the inflammatory factors levels,the acute physiology and chronic health evaluation system （APACHEⅡ） score,coagulation related indexes and cardiac injury related indexes before and after treatment were compared between the two groups. Results The total treatment effective rate was 94.12% in the observation group,which was significantly higher than that in the control group （ P 〈0.05）.After treatment,the levels of serum tumor necrosis factor-α （TNF-α）,C-reactive protein （CRP） and interleukin-6 （IL-6） with （49.53±12.66） ng/L,（6.49±2.08） mg/mL and （ 22.65± 12.49 ） pg/mL in the observation group were significantly lower than those in the control group （ P 〈0.05）,and the score of APACHEⅡwith （12.28±3.22） points was significantly lower than that in the control group （ P 〈0.05）.After treatment,the levels of D-dimer （D-D） and fibrinogen （FIB） were （6.25±1.14） mg/L and （ 2.47± 0.51） g/L respectively in the observation group,which were significantly lower than those in the control group （ P 〈0.05）.And the protein C activity with （122.74±16.38）% was significantly higher than that in the control group （ P 〈0.05）.After treatment,the levels of cardiac troponin I （cTnI）,creatine kinase isoenzyme （CK-MB） and lactate dehydrogenase isoenzyme （LDH-1） were （0.13±0.12） ng/mL,（ 23.64± 12.54 ） U/L and （52.66±19.56） U/L in the observati

关 键 词：舒血宁 重症急性胰腺炎 高凝状态 心脏损伤 

分 类 号：R657.51[医药卫生—外科学]