小剂量他巴唑治疗甲亢患者的效果观察  

Observation of effects of low-dose Methimazole in treatment of patients with hyperthyroidism

作　　者：李云[1] LI Yun(Department of Physical Examination of Nanyang Second General Hospital,Nanyang,Henan 473012,China)

机构地区：[1]南阳市第二人民医院体检科,河南南阳473012

出　　处：《中国民康医学》2018年第16期91-92,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:观察小剂量他巴唑治疗甲亢患者的效果。方法:选取甲亢患者164例作为研究对象。按照随机数字表法将其分为观察组和对照组各82例。对照组采用常规剂量他巴唑治疗,观察组采用小剂量他巴唑治疗。比较两组临床治疗效果、治疗前后血清TSH、FT4、FT3水平变化及不良反应发生情况。结果:对照组的治疗总有效率为92.7%(76/82),高于观察组的91.5%(75/82),差异无统计学意义(P>0.05),治疗2个月后,两组FT4、FT3均较治疗前明显降低,TSH明显升高,差异有统计学意义(P<0.05),组间差异无统计学意义(P>0.05);观察组不良反应发生率为7.3%(6/82),明显低于对照组的19.5%(16/82),差异有统计学意义(P<0.05)。结论:小剂量和常规剂量他巴唑治疗甲亢的疗效相当,小剂量的安全性优于常规剂量。Objective： To observe effects of low-dose of Methimazole in treatment of hyperthyroidism. Methods： A total of164 patients with hyperthyroidism were enrolled. According to the random number table method,they were divided into observation group（n = 82） and control group（n = 82）. The control group was treated with conventional doses of Methimazole,while the observation group was treated with low-dose Methimazole. The clinical effects of the two groups,serum TSH,FT4,FT3 levels and adverse reactions before and after the treatment were compared. Results： The total effective rate of the control group was 92.7%（76/82）,which was higher than 91.5%（75/82） of the observation group,and the difference was not statistically significant（P〉0.05）. 2 months after the treatment,the FT4 and FT3 levels of two groups was significantly lower than those before the treatment,the TSH levels were significantly increased,the differences were statistically significant（P〈0.05）; however,the differences between the groups were not statistically significant（P〉0.05）. The incidence of adverse reactions in the observation group was 7.3%（6/82）,significantly lower than the control group of 19.5%（16/82）,and the difference was statistically significant（P〈0. 05）. Conclusions： The efficacy of low-dose and conventional doses of Methimazole in the treatment of hyperthyroidism is comparable,but the safety of small doses is superior to conventional doses.

关 键 词：甲亢 小剂量他巴唑 安全性 

分 类 号：R581.1[医药卫生—内分泌]