miRNA在寄生虫宿主免疫调控中的研究进展  

miRNA functions in parasite-related immune regulation in hosts

作　　者：刘可 黄海斌 杨桂连 LIU Ke;HUANG Hai-bin;YANG Gui-lian(College of Animal Science and Technology,Jilin Provincial Engineering Probiotics,Jilin Agricultural University,Changchun 130118,China)

机构地区：[1]吉林农业大学动物科学技术学院吉林省动物微生态制剂工程研究中心,长春130118

出　　处：《中国寄生虫学与寄生虫病杂志》2018年第4期405-408,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家重点研发计划(No.2017YFD0501200);国家863计划(No.2013AA102806);国家自然科学基金(No.31272552);吉林省科技发展计划(No.20160519011JH;No.20170204034NY);吉林省产业创新专项资金(No.2016C063)~~

摘　　要：微小RNA(miRNA)是一种内源性小分子RNA,其通过转录后具有调控基因的功能,参与生理和病理过程的调控。目前,miRNA在寄生虫同宿主相互作用中的功能探索成为研究热点,包括寄生虫产生miRNA的传播方式、调控免疫应答反应、在中间宿主中的调控作用,以及其调控寄生虫感染的免疫病理学作用等。本文对上述研究进展进行了综述,以期为寄生虫致病机制的深入研究提供思路。Micro RNAs（miRNAs） are endogenous small-molecule RNAs that participate in the regulation of physiological and pathological processes through post-transcriptional regulation of gene expression. Exploring the functions of mi RNAs in host-parasite interactions has become a research focus these years, with topics including the transmission of miRNAs from parasites, the mi RNA-mediated regulation of host immune responses, the intermediate host responses, and the immunopathological effects induced by parasite infection. In this review we summarize the latest studies on these topics in order to provide new insights for further research on pathogenesis mechanisms of the parasites.

关 键 词：寄生虫 MIRNA 免疫调控 

分 类 号：R38[医药卫生—医学寄生虫学]