HPV感染与鼻内翻性乳头状瘤复发及恶变相关的Meta分析  

Meta-analysis of association between human papilloma virus infection with recurrence and malignant transformation of sinonasal inverted papilloma

作　　者：王茂华 于爱民[2] 关兵[2] 戴炳译 严齐 何庆庆 WANG Mao-hua;YU Ai-min;GUAN Bing;DAI Bing-yi;YAN Qi;HE Qing-qing(Department of Otolaryngology-Head and Neck Surgery,Second Xiangya Hospital,Central South University,Changsha 410011,China;Department of Otolaryngology-Head and Neck Surgery,Subei People＇s Hospital of Jiangsu Province,Yangzhou 225001,China;Department of Otolaryngology-Head and Neck Surgery,Drum Tower Hospital Affiliated to Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]中南大学湘雅二医院耳鼻咽喉头颈外科,湖南长沙410011 [2]江苏省苏北人民医院耳鼻咽喉头颈外科,江苏扬州225001 [3]南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科,江苏南京210008

出　　处：《中国耳鼻咽喉颅底外科杂志》2018年第4期350-355,360,共7页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的探讨人乳头状瘤病毒(HPV)与鼻腔鼻窦内翻性乳头状瘤(SNIP)发生、复发及恶变的关系。方法检索Pubmed、Web of science、Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库,查找2000~2017年国内外公开发表的HPV与SNIP发生、复发及恶变相关的所有病例对照研究文献,应用RevMan 5.3统计软件对各研究原始数据进行统计分析。结果 Meta分析示SNIP组HPV感染率明显高于对照组(P<0.01,OR=19.72,95%CI为7.91~49.18);复发组HPV感染率明显高于对照组(P<0.01,OR=3.10,95%CI为1.90~5.08);恶变组HPV感染率明显高于对照组(P<0.01,OR=2.09,95%CI为1.41~3.09)。结论 HPV感染与SNIP的发生、复发及恶变密切相关。Objective To discuss the relationship between human papilloma virus （HPV） and recurrence as well as malignant transformation of sinonasal inverted papilloma （SNIP）. Methods Published articles of case-control study about the relationship between HPV and recurrence as well as malignant transformation of SNIP were selected from Pubmed, Web of science, Embase, Cochrane Library, CNKI, VIP, Wanfang database and Chinese HowNet （2000-2017）. All paper were reviewed and the original data were analyzed statistically by using RevManS. 3 statistical software. Results Meta analysis showed that HPV infection rate of the SNIP group was significantly higher than that of the control group （P 〈 0. 00001, OR = 19.72, 95% CI =7.91 ~49.18） , and those of the recurrence group, malignant transformation group were also significantly higher than that of the control group （ P 〈 0. 00001, OR = 3.10, 95% CI = 1.90 - 5.08 ; P = 0. 0002, OR =2.09, 95% CI, = 1.41 - 3.09）, respectively. Conclusion HPV infection is closely related to the occurrence, recurrence as well as malignant transformation of SNIP.

关 键 词：人乳头状瘤病毒 鼻腔鼻窦内翻性乳头状瘤 复发 恶变 META分析 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]