Lignans and flavonoids from Artemisia brachyloba  

山蒿中木脂素和黄酮类化学成分研究（英文）

作　　者：Puming Zhang Chen Zhang Kewu Zeng Yong Jiang Pengfei Tu 张圃铭;章宸;曾克武;姜勇;屠鹏飞(北京大学医学部药学院天然药物及仿生药物国家重点实验室,北京100191)

机构地区：State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2018年第6期429-435,共7页中国药学（英文版）

基　　金：National Natural Science Foundation of China(Grant No.81373294);National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2018ZX09711001-008-003)

摘　　要：A phytochemical investigation on the aerial parts of Artemisia brachyloba led to the isolation of 13 compounds（1-13） for the first time, including eight lignans（1-8） and five flavonoids（9-13）. The structures of the isolated compounds were elucidated by analysis of the NMR spectroscopic data and comparison with the literature. The 1 H and 13 C NMR data of 1 were fully assigned for the first time by the 2 D NMR analysis. All the isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-challenged BV-2 microglial cells.运用硅胶柱色谱、反相硅胶柱色谱、Sephadex LH-20柱色谱及半制备HPLC等多种分离方法对山蒿化学成分进行了研究,分离得到13个化合物,通过NMR数据分析,并结合文献对比,鉴定了化合物的结构,其中8个木脂素和5个黄酮,均为首次从山蒿中分离得到。借助2D NMR技术首次对化合物1的波谱数据进行了全归属。对分离到的所有化合物进行了抑制脂多糖诱导的BV-2小胶质细胞NO生成实验,化合物1,4和10有一定的抑制NO生成活性。

关 键 词：Artemisia brachyloba Lignans FLAVONOIDS NO 

分 类 号：R284[医药卫生—中药学]