血清白介素-8、白介素-18与慢性阻塞性肺疾病、支气管哮喘及支气管扩张的相关性研究  

Study on the Relationship Between Serum Interleukin-8,Interleukin-18 and Chronic Pulmonary Disease,Bronchial Asthma,Bronchiectasis

作　　者：岳文香[1] 陈愉生[1] 谢宝松[1] 李瑞慧[1] 许能銮[1] 林明[1] YUE Wen-xiang;CHEN Yu-sheng;XIE Bao-song(Fujian Provincial Medical College,Fujian Medical University,Department of Pulmonary and Critical Care Medicine,Fujian Provincial Hospital,Fuzhou,350001,China)

机构地区：[1]福建医科大学省立临床医学院福建省立医院呼吸与危重症医学科,福州350001

出　　处：《黑龙江医学》2018年第9期853-855,共3页Heilongjiang Medical Journal

基　　金：福建省卫生系统中青年骨干人才培养项目(项目编号:2014-ZQN-JC-4);福建省2014年临床重点专科资助项目(闽卫医政函[2015]593号)

摘　　要：目的探讨血清白介素(IL)-8及IL-18的表达与慢性阻塞性肺疾病(COPD)、支气管哮喘(哮喘)及支气管扩张(支扩)的相关性。方法 2014年12月—2016年3月于福建省立医院呼吸科病房住院的有阻塞性肺通气功能障碍的三种COPD患者共91例,其中急性加重期COPD组30例,急性发作期哮喘组31例,急性加重期支扩组30例,及同期正常对照组33例,皆抽取空腹外周血3 ml,采用酶联免疫吸附测定(ELISA)法测定其血清IL-8、IL-18;三种疾病好转期于入院后1周抽取空腹外周血3ml,再用ELISA测定IL-8、IL-18。统计分析急性加重期与好转期的血清IL-8、IL-18变化。结果COPD急性加重期IL-8为(921.3±627.7)μg/L,低于好转期的(1 287.9±1 186.3)μg/L,差异有统计学意义(P<0.05);哮喘急性发作患者的IL-8(883.2±578.7)μg/L亦低于好转期值的(1 229.4±1 070.3)μg/L,差异有统计学意义(P<0.05);而支扩组急性期[(840.1±552.4)μg/L]与好转期IL-8变化不明显[(950.4±732.8)μg/L,差异无统计学意义(P>0.05)]。支扩组患者IL-18表达最低,明显低于正常对照组、COPD组和哮喘组(P<0.001),但三种疾病急性期和好转期的血清IL-18变化不明显(P>0.05)。结论急性期COPD和哮喘患者血清IL-8随着疾病的好转早期呈特异性上升趋势,而支扩组患者IL-8无特异性的上升或降低。支扩组IL-18表达水平最低,但三种疾病患者急性期和好转期血清IL-18变化无特异性的上升或降低。Objective To study the relationship between serum interleukin - 8,interleukin - 18 and chronic obstructive pulmonary disease （COPD） ,bronchial asthma,and bronchiectasis. Methods 91 patients with chronic pulmonary diseases admitted in Respiratory ward of Fujian Provincial Hospital from December,2014 to March,2016 were included.Among these patients,there were 30 patients with acute exacerbation of COPD,31 patients with acute attack of bronchial asthma,and 30 patients with acute exacerbation of bronchiectasis.33 healthy controls from normal people of health examination were included as control group at the corresponding period.Each individual had the extraction of peripheral blood 3 ml on an empty stomach.The IL - 8 and IL - 18 levels were determined by enzyme - linked immunosorbent assay （ELISA） .About 7 days after admission,in improved period,all had the extraction of peripheral blood 3 ml for IL - 8,IL - 18 detection determined by ELISA.These data were analyzed statistically. Results The serum IL - 8 levels of COPD patients in acute exacerbation period were lower than that in improvenmet period[ （921.3±627.7） vs （1 287.9± 1 186.3 ） μg/L, P 〈0.05].The serum IL - 8 levels of asthma patients in acute period were also lower than that in improvement period （1 229.4±1 070.3） μg/L, P 〈0.05.There was no significant difference of the serum IL - 8 levels in the bronchiectasis patients between acute and improvement period （950.4±732.8） μg/L, P 〉0.05.The serum IL - 18 levels of the bronchiectasis group were the lowest especially （ P 〈0.001） .However,there were no significant difference of the serum IL - 18 levels of the patients with three diseases between acute period and improvement period. Conclusion The IL - 8 levels were increased specifically in the early stage in COPD and asthma group in acute exacerbation period,but there were no significant changes in bronchiectasis group.The serum IL - 18 levels of the bronchiectasis group were the lowest specifically.However,there was n

关 键 词：白细胞介素8 白细胞介素18 慢性阻塞性肺疾病 支气管哮喘 支气管扩张 

分 类 号：R563[医药卫生—呼吸系统] R562.25[医药卫生—内科学]