青春期哮喘患者气道反应性与气道炎症情况分析  

Airway Responsiveness and Inflammation in Patients with Adolescent Asthma

作　　者：李小乐[1] 徐勇胜[1] 任立歆[1] 万莉雅[1] LI Xiao-le;XU Yong-sheng;REN Li-xin(Department of Respiration,Tianjin Children s Hospital,Tianjin,300134,China)

机构地区：[1]天津市儿童医院呼吸科,天津市300134

出　　处：《黑龙江医学》2018年第9期860-862,共3页Heilongjiang Medical Journal

摘　　要：目的了解症状缓解后青春期哮喘患者的肺结构与功能、气道炎症变化特征。方法选择天津市儿童医院就诊的青春期哮喘患者58例,分为症状缓解组和现症哮喘组,进行支气管激发试验和气道炎症指标检测。结果症状缓解组和现症哮喘组在气道敏感性方面差异无统计学意义,症状缓解组TGF-β水平高于现症哮喘组,差异有统计学意义(P<0.01),而IL-4和INF-γ水平差异无统计学意义。结论青春期哮喘患者尽管症状减轻或消失,气道炎症及重塑依旧存在。Objective To investigate the characteristics of lung structure,function and airway inflammation in patients with adolescent asthma after symptoms remission. Methods A total of 58 patients from Tianjin Children s Hospital of adolescent asthma patients were selected,and they were divided into remission group and acute asthma group to do in bronchial provocation test and airway inflammationtest. Results There was no significant difference in the airway sensitivity between remission group and current asthma group,TGF - β level of remission asthma group was higher than the current asthma group.The difference was statistically significant （ P 〈0.01） ,but there was no significant difference in the IL - 4 and INF - γ levels. Conclusion The airway inflammation and remodeling still exist in patients with adolescent asthma despite the reduction or disappearance of symptoms.

关 键 词：哮喘 青春期 缓解 

分 类 号：R725.6[医药卫生—儿科]