外泌体对骨关节炎的影响  

Effect of Exosomes on Osteoarthritis

作　　者：周绪昌 李慧 邹军[2] 王淼[1] Zhou Xuchang;Li Hui;Zou Jun;Wang Miao(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China;DeveIopment and Planning Office,Shanghai University of Sport,Shanghai 200438,China)

机构地区：[1]上海体育学院运动科学学院,上海200438 [2]上海体育学院发展规划处,上海200438

出　　处：《中国细胞生物学学报》2018年第8期1402-1407,共6页Chinese Journal of Cell Biology

基　　金：上海市人类运动能力开发与保障重点实验室项目(上海体育学院)(批准号:11DZ2261100)资助的课题~~

摘　　要：骨关节炎(osteoarthritis,OA)的发病主要与关节内生物力学改变、关节软骨磨损以及合成分解代谢紊乱有关。关节内代谢平衡主要依靠一系列细胞内分子(激酶级联、自噬、转录因子和表观遗传机制等)和细胞外刺激(细胞因子、激素和机械应力等)的调节。外泌体作为一种分泌到细胞外发挥作用的囊泡状物质,广泛参与细胞间信息交流。外泌体能够通过内部含有的m RNA、miRNA和蛋白质等生物活性分子对骨关节炎病程发展产生一定的影响,且不同干细胞来源的外泌体对OA的作用存在一定的差异。该文通过综述近年来有关外泌体对骨关节炎疗效研究的文献报道,为后续进一步探究外泌体对OA作用机制及其相关研究提供理论参考和依据。The occurrence of osteoarthritis（OA） mainly associated with intra-articular biomechanics changes, cartilage damage and synthetic catabolic dysfunction. The homeostatic balance of joint is regulated by intracellular molecules such as kinase cascades, autophagy, and transcription factors, epigenetic mechanisms and extracellular stimuli including cytokines, hormones and mechanical stress. Exosomes, as a vesicle-like substance secreted into the extracellular environment, are widely involved in intercellular communication. Exosomes contain m RNAs, micro RNAs and proteins and other bioactive molecules which can affect the progression of OA. Different stem cell-derived exosomes have some differences in their effects on OA. This article summarizes literatures about the effect of exosomes on OA in recent years to provide a further basis for the research of OA pathogenesis and treatment.

关 键 词：外泌体 骨关节炎 间充质干细胞 

分 类 号：R684.3[医药卫生—骨科学]