舌的发育及其调控机制  

Regulation Mechanisms of Tongue Development

作　　者：李艳[1] 俞姣姣 李浩然 李斐雪 Li Yan;Yu Jiaojiao;Li Haoran;Li Feixue(College of Life and Environmental Science,Hangzhou Normal University,Hangzhou 310036,China)

机构地区：[1]杭州师范大学生命与环境科学学院,杭州310036

出　　处：《中国细胞生物学学报》2018年第8期1424-1429,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:81670971);杭州市农业科研自主申报项目(批准号:20180432B02)资助的课题~~

摘　　要：舌是参与咀嚼、吸允、吞咽、发音等功能的重要器官。舌发育异常会导致无舌、小舌、舌裂、结舌、巨舌症、腭裂等严重的先天舌发育缺陷疾病。发育完全的舌由肌肉组织、结缔组织、黏膜组织及血管组成。调控舌发育的基因有Pax3/Pax7、Dlx基因家族、TGF-β家族和FGF等,同时还受Shh与Wnt等信号通路调控。舌发育分子调控机制的研究对相关舌发育畸形疾病的诊断与治疗有重要意义。Tongue is an important organ involved in chewing, swallowing, pronunciation. Abnormal tongue development will lead to aglossia, microglossia, bifid tongue, ankyloglossia, macroglossia and cleft palate. The normal tongue is composed of muscle, connective tissue, mucosal tissue and blood vessels. Paired box gene Pax3 and Pax7, Dlx genes, TGF-β and FGF genes have been proved to be critical for tongue development. Shh and Wnt signaling pathways are also involved in the regulation of tongue development. The study of molecular mechanism will contribute greatly to the diagnosis and treatment of diseases of tongue development.

关 键 词：舌 颅面神经嵴细胞 鳃弓 肌原祖细胞 调控机制 

分 类 号：Q344[生物学—遗传学]