齐齐哈尔市2009—2016年手足口病病原学监测结果分析  

Analysis of the Pathogenicity of Hand,Foot and Mouth Disease in Qiqihar City from 2009 to 2016

作　　者：袁兵[1] 果春杰[1] 胡晓瑛 施京利[1] YUAN Bing;GUO Chun-jie;HU Xiao-ying;SHI Jing-li(Qiqihar City Center for Disease Control and Prevention,Qiqihar,Heilongjiang,161006)

机构地区：[1]齐齐哈尔市疾病预防控制中心,黑龙江齐齐哈尔161006

出　　处：《黑龙江医学》2018年第8期763-765,769,共4页Heilongjiang Medical Journal

摘　　要：目的分析齐齐哈尔市手足口病病原学监测结果,为制定防控策略和措施提供参考依据。方法收集2009-2016年间齐齐哈尔市各县(区)疾病预防控制中心及齐齐哈尔市第七医院所采集的手足口病例咽拭子,采用实时荧光PCR技术进行EV通用型、EV71型和CoxA16型的核酸检测。结果共检测手足口病普通病例1 151人,检出阳性649例,阳性率为56.39%.阳性检出EV71型(55.16%),CoxA16型(31.90%),其他EV通用型(12.94%);不同年份阳性率不同(χ~2=137.32,P<0.05),不同年份病原构成不同(χ~2=268.04,P<0.05)。重症病例检测104例,检出阳性76例,阳性率为73.08%;阳性检出EV71型(96.05%),其他EV通用型(3.95%)。重症病例与普通病例的EV71阳性率差异有统计学意义(χ~2=64.63,P<0.05)。男性病例阳性率高于女性,发病人群以5岁以下儿童为主。结论不同年度手足口病病原谱构成不同,应加强手足口病监测工作并根据当年监测结果制定有针对性的控制策略和措施。Objective To analyze the etiology of HFMD in Qiqihar city and provide reference for the prevention and control strat- egies of HFMD. Methods Collecting pharyngeal swabs of patients with HFMD, which were collected by the Centers for Disease Con- trol in Qiqihar counties（districts） and Qiqihar No. 7 Hospital from 2009 to 2016, and detecting nucleic acid of EV universal type, EV71 type and CoxA16 type using real-time fluorescence PCR technology. Results 1 151 ordinary cases with HFMD were detected, among them 649 cases were positive, and the positive rate was 56. 39 %. The positive detection was EV71 （55.16 % ）, CoxA16 （31.90 % ）, and other EV generic（ 12. 94 % ） ; The positive rate was different in different years（x2 = 137. 32, P 〈0. 05）, and the pathogen composition was different in different years（X2 = 268. 04, P 〈 0. 05）. 104 cases of severe cases were tested, among them 76 cases were positive, and the positive rate was 73.08 %. 96. 05 % of the positive results were the type of EV71, and the other EV general types were 3.95 % detected. In the EV71 positive rate, there was a significant difference between severe cases and ordinary cases （X2 = 64. 63, P 〈 0. 05）. The positive rate of male cases was higher than that of females, and the children under the age of 5 were the high risk population. Conclusion The pathogen spectrum composition of HFMD is different in different years. It is necessa- ry to strengthen the monitoring of HFMD in different years, and to formulate specific control strategies and measures based on the re- suits of the monitoring in that year.

关 键 词：手足口病 病原 监测 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]