禽霍乱、新城疫二联灭活苗与单苗比较试验  

Comparative study between inactivated bivalent vaccine and monovalent vaccines against fowl cholera and Newcastle disease

作　　者：王红琳[1] 汪宏才[1] 罗青平[1] 温国元[1] 罗玲[1] 张蓉蓉[1] 张腾飞[1] 卢琴[1] 邵华斌[1] WANG Honglin;WANG Hongcai;LUO Qingping;WEN Guoyuan;LUO Ling;ZHANG Rongrong;ZHANG Tengfei;LU Qin;SHAO Huabin(Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding,Ministry of Agriculture Key Laboratory of Prevention and Control Agents for Animal Bacteriosis,Institute of Animal Husbandry and Veterinary,Hubei Academy of Agricultural Sciences,Wuhan 430064,China)

机构地区：[1]湖北省农业科学院畜牧兽医研究所/农业部畜禽细菌病防治制剂创制重点实验室/动物胚胎工程及分子育种湖北省重点实验室

出　　处：《黑龙江畜牧兽医》2018年第16期165-167,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：现代农业产业技术体系建设专项资金资助项目(CARS-42-G11);湖北省农业科技创新中心项目(2016-620-004-003);动物胚胎工程及分子育种湖北省重点实验室项目(2017ZD108)

摘　　要：为了科学地评价禽霍乱、新城疫二联灭活疫苗的安全性及免疫效果,试验将二联苗分别与鸡新城疫灭活疫苗（La Sota株）和禽多杀性巴氏杆菌病灭活疫苗（1502株）在同等条件下进行了性状和无菌检验,并进行了安全和效力比较试验。结果表明：二联苗与两种单苗的性状和无菌检验均合格,安全和效力试验结果无明显差异。说明二联苗产品质量不亚于两种单苗,且实现了一针防两种病的目的。In order to scientifically evaluate the safety and immune response of inactivated bivalent vaccine against fowl cholera and newcastle disease, morphological and sterility tests were performed in this experiment on equal conditions between the bivalent vaccine and inactivated newcastle disease vaccine （ La Sota isolate） or inactivated vaccine against avian pasteurellosis （ 1502 isolate）. The comparison of safety and effica- cy tests was also carried out. The results showed that both the bivalent vaccine and two monovalent vaccines were qualified under morphological and sterility tests,and had no significant difference under safety or efficacy tests. The results suggested that the quality of the bivalent vaccine was not less than those of two monovalent vaccines,and the bivalent vaccine could achieve the aim of the prevention of two diseases by single dose.

关 键 词：禽霍乱 新城疫 二联苗 单苗 安全 效力 

分 类 号：S852.5[农业科学—基础兽医学]