血浆NO和HMGB1对评估CO中毒迟发性脑病的预测价值  

Value of serum NO and HMGB1 in predicting delayed encephalopathy after CO poisoning

作　　者：陈建霞 庄美平 缪羽 陈丽娟 Chen Jianxia;Zhuang Meiping;Miao Yu;Chen Lijuan(Deparment of Emergency,Hospital 180 of PLA,Quanzhou,Fujian,362000,China;Outpatient Deparment,Hospital 180 of PLA,Quanzhou,Fujian,362000,China;Deparment of Nursing,Hospital 180 of PLA,Quanzhou,Fujian,362000,China)

机构地区：[1]解放军180医院急诊科,福建泉州362000 [2]解放军180医院门诊部,福建泉州362000 [3]解放军180医院护理部,福建泉州362000

出　　处：《西南国防医药》2018年第9期851-853,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨血浆一氧化氮(NO)、高迁移率族蛋白1(HMGB1)在评估一氧化碳(CO)中毒迟发性脑病中的预测价值。方法将本院收治的70例CO中毒患者按是否发生迟发性脑病分为脑病组(n=32)与无脑病组(n=38),并选择同期来医院体检的40例正常健康人作为对照组,均采集外周血标本,测定血浆NO、HMGB1水平,分析NO、HMGB1在预测CO中毒迟发性脑病发病中的价值。结果脑病组、无脑病组NO水平低于对照组,HMGB1水平高于对照组(P <0.05);与入院第1 d比较,入院第5、10 d,脑病组、无脑病组血浆NO水平均上升,HMGB1水平均降低(P <0.05),其中脑病组入院1、5、10 d血浆NO低于无脑病组,而HMGB1水平高于无脑病组(P <0.05)。结论 CO中毒迟发性脑病患者伴明显血浆NO降低和HMGB1表达上调特点,两者动态变化可作为预测CO中毒患者迟发性脑病发生的指标。Objective To explore the value of serum nitric oxide （NO） and high mobility group box 1 （HMGBI） in predicting delayed encephalopathy after carbon monoxide （CO） poisoning. Methods A total of 70 patients with CO poisoning admitted to our hospital were selected and divided into an encephalopathy group（n=32） and a non-encephalopathy group （n=38） according to whether delayed encephalopathy occurred. Another 40 normal and healthy subjects who had received physical examination in the hospital during the corresponding period were selected as a control group. Peripheral blood （PB） specimens were collected to detect the levels of plasma NO and HMGBI and analyze the value of NO and HMGBI in predicting delayed encephalopathy after CO poisoning. Results The NO levels in the encephalopathy group and the non-encephalopathy group were lower than those in the control group, while HMGBI levels were higher than those in the control group （P 〈 0.05）; compared with the first day upon admission, on the fifth and tenth days upon the admission, the plasma NO levels in the encephalopathy group and the non-encephalopathy group increased, while the HMGG1 levels in the two groups decreased （P 〈 0.05）. The plasma NO levels on the first, fifth and tenth days upon the admission in the encephalopathy group were lower than those in the non-encephalopathy group, while the HMGBI levels were higher than those in the non-encephalopathy group（P 〈 0.05）. Conclusion The patients with delayed encephalopathy after CO poisoning are complicated with obvious plasma NO decrease and up-regulation of HMGBI. The dynamic changes in plasma NO and HMGBI can be used as the indicators tor predicting delayed encephalopathy in patients with CO poisoning.

关 键 词：一氧化碳 中毒 迟发性脑病 一氧化氮 高迁移率族蛋白 预测 

分 类 号：R136.3[医药卫生—劳动卫生]