两种主动载药的伊立替康脂质体释药行为的对比考察  

Comparative study on the release behaviors of irinotecan loaded liposomes with two active loading methods

作　　者：吴刚 周玉洁 魏悦蕾 周卫[1] WU Gang;ZHOU Yu-jie;WEI Yue-lei;ZHOU Wei(School of Pharmacy,China Pharmaceutical University,Zhe-jiang Nanjing 210009,China)

机构地区：[1]中国药科大学药学院,江苏南京210009

出　　处：《中国医院药学杂志》2018年第16期1686-1689,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:建立体外释放测定方法,考察两种方法制备的盐酸伊立替康脂质体的体外释药特性。方法:以含有铵离子的PBS作为释放介质,采用微柱离心法分离样品,考察以蔗糖八硫酸酯三乙胺梯度法和硫酸铵梯度法制备的伊立替康脂质体的体外释放。结果:两种方法制备的载药脂质体在PBS中24 h释放度分别为43.3%、89.8%。结论:两种伊立替康脂质体的体外释放行为存在明显差异,以蔗糖八硫酸酯三乙胺梯度法制备的伊立替康脂质体改善了药物的滞留。OBJECTIVE To establish an in vitro release assay and investigate the release characteristics of irinotecan hydrochloride liposomes prepared by two methods in vitro.METHODS PBS containing ammonium ions was used as the release medium,the samples were separated by microcolumn centrifugation method,the release in vitro of irinotecan liposome prepared by the triethylammonium sucrose octasulfate gradient method and ammonium sulfate gradient method was investigated.RESULTS The release rates of the liposomes prepared by the two methods were 43.3% and 89.8%in PBS at 24 h,respectively.CONCLUSION The release behaviors of the two irinotecan liposomes are obviously different.The liposomes prepared by the triethylammonium sucrose octasulfate gradient method improve the retention of the drugs.

关 键 词：盐酸伊立替康 脂质体 体外释放 

分 类 号：R944[医药卫生—药剂学]