P_1PK血型抗原研究进展  

Research progress of P_1PK blood group antigen

作　　者：范春丽[1] 李树中[1] 李中华 叶小英[1] 胡氏月 李凌波 FAN Chunli;LI Shuzhong;LI Zhonghua

机构地区：[1]江苏大学附属昆山第一人民医院,江苏昆山215300 [2]黑龙江省牡丹江市第二人民医院 [3]长春博讯生物技术有限责任公司

出　　处：《临床血液学杂志（输血与检验）》2018年第4期643-648,共6页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：2011年国际输血协会（ISBT）确认了P1PK血型系统的抗原,命名为P1PK,编号003。确认该系统有3个抗原,分别是：P1,PK,NOR。本文就目前对P1PK系统抗原的研究进展,做一扼要概述。并针对＂P抗原＂在多年的研究过程中,经历的定义不清、命名混乱,以及目前还存在的一些模糊认识、错误观点加以澄清[1-4]。In 2011,ISBT reconfirmed three antigens of P1PK blood group system and clarified the definition of related antigens.The three antigens of the P1Pk blood group belong to the paracosides and glycoside antigens respectively.It has been confirmed that the gene of this antigen is A4GALT and three exon sequences,and the encoded glycosyltransferase has 353amino acids.Gene mutations occur mainly in exon 3.P1PK blood group antibodies have cold antibodies and autoantibodies,individual can cause hemolysis.This article describes the latest research progress of the antigen,and clarifies some past mistakes and vague understanding.

关 键 词：糖苷类抗原 副糖苷类抗原 冷抗体 自身抗体 

分 类 号：R392.11[医药卫生—免疫学]